REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1620209
This article is part of the Research TopicCommunity Series in Recent Advances in Potential Biomarkers for Rheumatic Diseases and in Cell-based Therapies in the Management of Inflammatory Rheumatic Diseases: Volume IIIView all 4 articles
Mechanistic and Therapeutic Insights into the Function of Different Cell Death Modalities in Rheumatoid Arthritis: Emphasis on the Crosstalk with Non-coding RNAs
Provisionally accepted
- Anhui University of Chinese Medicine, Hefei, China
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Rheumatoid arthritis (RA), a prevalent autoimmune disorder, imposes a substantial burden on global health due to its progressive disability and compromised patient well-being. Although the precise etiology of this condition is still not fully understood, current research implicates intricate interactions between dysregulated immune cells and pro-inflammatory mediators. Recent scientific advancements have highlighted the pathogenic significance of programmed cell death (PCD) mechanisms (including spanning apoptosis, autophagy, ferroptosis, necroptosis, senescence, and pyroptosis) in RA pathophysiology. Emerging evidence has established these cellular demise pathways as critical contributors to synovial inflammation and joint destruction. This comprehensive analysis systematically examined the mechanistic involvement of distinct cell death modalities in RA development, with particular focus on their regulatory interplay with non-coding RNAs (ncRNAs). Furthermore, the emerging therapeutic potential of traditional Chinese medicine (TCM) formulations in modulating these cell death networks was evaluated, ultimately proposing novel translational frameworks for targeted RA intervention.
Keywords: Rheumatoid arthritis, Different cell death modalities, non-coding RNAs, Mechanistic and therapeutic, TCM
Received: 29 Apr 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Wen, Liu, Wan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jian Liu, Anhui University of Chinese Medicine, Hefei, China
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