REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1620895
Molecular pathology of lymphoma and its treatment strategies: from mechanistic elucidation to precision medicine
Provisionally accepted
- 1The First People’s Hospital of Yunnan Province, Kunming, China
- 2Xiyuan Hospital, China Academy of Chinese Medical Sciences, bei jin, China
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Lymphoma is a highly heterogeneous hematologic malignancy characterized by intricate molecular and pathological mechanisms. Key mechanisms contributing to its complexity include malignant clonal evolution driven by somatic mutations, epigenetic modifications affecting gene regulation and cellular behavior, and dynamic tumor microenvironment remodeling. These factors collectively undermine the efficacy of conventional therapeutic strategies. Differences in the molecular mechanisms of different subtypes lead to heterogeneity in treatment response and recurrence of drug resistance. Current and future investigative priorities emphasize molecular stratification, precision diagnosis and therapeutic strategies, advancement of novel diagnostic tools, and the implementation of artificial intelligence (AI) for integrative analysis of high-dimensional biological data. Moreover, emerging areas such as microbiome-targeted interventions are being explored to improve clinical outcomes and support the evolution of precision oncology in lymphoma treatment.
Keywords: Lymphoma, precision medicine, Immunotherapy, Nanotechnology, artificial intelligence
Received: 30 Apr 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Wang, Feng, Yao, li, Zheng, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zengzheng Li, The First People’s Hospital of Yunnan Province, Kunming, China
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