REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1620965
Intestinal injury signaling pathway in sepsis
Provisionally accepted
- Yangtze University, Jingzhou, China
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Sepsis is a syndrome of inflammatory response syndrome (SIRS) triggered when the host is exposed to bacterial, viruses, and other infectious agents. The resulting inflammation compromises intestinal integrity, and this gut injury subsequently amplifies systemic inflammation, ultimately leading to multiple organ failure. This review synthesizes recent advances in sepsis-induced intestinal injury, focusing on four key aspects: pathogenesis, molecular mechanisms, crosstalk among relevant signaling pathways, and therapeutic strategies. Our analysis reveals extensive interactions between these signaling pathways, with most being critically dependent on nuclear factor-kappa B (NF-κB). We propose that the nuclear factor-κB signaling pathway serves as a central hub in the mechanistic network of septic gut injury. By delineating the interplay of signaling pathways in intestinal damage during sepsis. This work aims to provide novel therapeutic perspectives.
Keywords: Sepsis, Intestinal injury, NF-κB, signaling pathway, Inflammatory Response
Received: 30 Apr 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Liu, Yue, Chen, Liu and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xinyi Zeng, Yangtze University, Jingzhou, China
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