ORIGINAL RESEARCH article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1622499
This article is part of the Research TopicExploring Microglial Diversity and Its Impact on Neurological DiseasesView all 4 articles
Global Research Hotspots and Trends in Microglia in Ischemic Stroke
Provisionally accepted
- 1The First Clinical College of Anhui University of Chinese Medicine, HeFei, China
- 2Graduate School Anhui University of Chinese Medicine, HeiFei, China
- 3The Second Affiliated Hospital of Anhui University of Chinese Medicine, HeFei, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: This study explores potential therapeutic strategies by analyzing the bibliometric analysis of microglia in ischemic stroke (IS) to identify the current status, hotspots, and trends in research. Methods: In this study, we visualized publications on IS and microglia indexed in the Web of Science Core Collection between January 1, 2010, and March 15, 2025, using VOSviewer and CiteSpace software. In addition, we optimized several visualization maps using Pajek and Scimago Graphica to present the analysis results more clearly and intuitively. Results: A total of 2,117 articles and reviews from 465 journals were included in the analysis. The number of publications reveals a steady increase over the years. China and the United States lead the field in terms of influence. Jun Chen from the University of Pittsburgh is the most influential scholar, and the Journal of Neuroinflammation is the most frequently cited journal among researchers. Through visual analysis of subject categories, keywords, and references, we found neuroinflammation to be the central mechanism in this research area. Therapeutic approaches primarily focus on using mesenchymal stem cells and extracellular vesicles, representing one of the most promising translational strategies for treating IS. Furthermore, innovative applications of neuroimaging technology and nanotechnology are facilitating the translation of basic research into clinical practice. Conclusion: This study uses bibliometric methods to summarize key findings in microglia-related IS research. The insights gained will provide valuable guidance and reference for developing new immunotherapeutic strategies based on microglia for more effective prevention and treatment of IS.
Keywords: Microglia, ischemic stroke, Neuroinflammation, bibliometric analysis, visual analysis
Received: 03 May 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Liu, Ye, Dai, Bai, Ji, Su, Hu and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Peijia Hu, zjyyhpj@163.com
Hongliang Cheng, chl.75811@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.