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REVIEW article

Front. Immunol.

Sec. Cancer Immunity and Immunotherapy

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1623588

This article is part of the Research TopicTargeted Therapies in Gastric Cancer: Molecular Signatures and Immune Microenvironment InsightsView all 12 articles

Multimodal Therapeutic Strategies against Gastric Cancer: From Conventional Treatments to Tumor Microenvironment Targeting

Provisionally accepted
Xi YuanXi Yuan1,2Changxian ChenChangxian Chen1,2Yixuan PangYixuan Pang1,2Xuanzhi WangXuanzhi Wang3Tingting YangTingting Yang1,2Anying LongAnying Long1,2Na LiangNa Liang1,2Ying YangYing Yang1,2Chunming LiChunming Li1,2*
  • 1Department of Pathology, Zunyi Medical University, Zunyi, China
  • 2Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, China
  • 3The First Clinical Institute,Zunyi Medical University, Zunyi, China

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Gastric cancer is one of the most common malignant tumors of the digestive system, with persistently high global morbidity and mortality rates. The multi-level heterogeneity of the gastric cancer tumor immune microenvironment (TIME) is closely associated with treatment efficacy and prognosis. This heterogeneity is reflected not only in the types and functions of various cells within the microenvironment but also in multiple aspects such as molecular profiles, metabolic pathways, and the spatial distribution of tumor cells. Currently, the interaction between gastric cancer and its microenvironment, as well as the resulting immune evasion, has become a research hotspot. This article reviews the role of cellular heterogeneity and metabolic reprogramming in the gastric cancer Tumor Immune Microenvironment (TIME) in reshaping the immune microenvironment, and summarizes traditional therapies alongside existing and potential microenvironment-modulating treatment strategies.

Keywords: gastric cancer, Tumor immune microenvironment, heterogeneity of cell components, metabolic reprogramming, Immunotherapy

Received: 06 May 2025; Accepted: 25 Aug 2025.

Copyright: © 2025 Yuan, Chen, Pang, Wang, Yang, Long, Liang, Yang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Chunming Li, Department of Pathology, Zunyi Medical University, Zunyi, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material