TECHNOLOGY AND CODE article
Front. Immunol.
Sec. Viral Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1624020
Defining Criteria for Broadly Neutralizing HIV Antibodies
Provisionally accepted
Jennifer L. Mamrosh*
Elizabeth-Sharon David-FungKatherine A BelobrajdicJennifer P Macke
Corey R Quackenbush
Kumkum Ganguly- Los Alamos National Laboratory (DOE), Los Alamos, United States
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Over the course of a few years, a small percentage of individuals with HIV-1 develop broadly neutralizing antibodies (bnAbs) capable of neutralizing diverse viruses. Although hundreds of antibodies with neutralizing activity against heterologous viruses have been referred to as bnAbs, there is no universally accepted numerical definition of a bnAb. Here, we will review important elements of HIV neutralizing antibodies and proposed definitions of bnAbs, as well as introduce a web-based tool, CAByN (Choose Antibodies by Neutralization) allowing users to identify antibodies meeting their numerical definitions of a bnAb from data in the Los Alamos HIV Databases CATNAP (Compile, Analyze and Tally NAb Panels) antibody neutralization database. Biological findings from use of CAByN are also presented here, including differential neutralizing activity for certain antibodies across viral clades, and identification of antibodies with suspected incomplete neutralization.
Keywords: HIV, broadly neutralising antibodies, BNAB, Antibody breadth, Potency
Received: 06 May 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Mamrosh, David-Fung, Belobrajdic, Macke, Quackenbush and Ganguly. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jennifer L. Mamrosh, Los Alamos National Laboratory (DOE), Los Alamos, United States
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