REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1625748
Tuberculosis in Patients with Systemic Lupus Erythematosus
Provisionally accepted
- 1Department of Biology, University of Oxford, Oxford, United Kingdom
- 2Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand
- 3Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, HatYai, Thailand
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Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M. tb), with approximately 10 million new cases reported worldwide annually. Patients with autoimmune diseases and immunocompromised states are at a high risk of M. tb infection. The chronic autoimmune disease, systemic lupus erythematosus (SLE), is associated with a higher risk of M. tb infection and TB disease during conventional treatment with corticosteroids and immunosuppressants. However, whether risk of TB is influenced by the immune disturbances associated with active SLE when patients are not receiving immunosuppressant treatment remains unclear. In this review, we describe the pathogenesis of TB and SLE and consider how autoimmune responses in SLE could influence TB risk.
Keywords: Tuberculosis, systemic lupus erythematosus, immunology, corticosteroids, Pathogenesis
Received: 09 May 2025; Accepted: 25 Jul 2025.
Copyright: © 2025 Ongarj, Intapiboon, Tanner and Pinpathomrat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nawamin Pinpathomrat, Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.