ORIGINAL RESEARCH article

Front. Immunol.

Sec. Cancer Immunity and Immunotherapy

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1627442

This article is part of the Research TopicEfficacy of Neoadjuvant Immunotherapy and Analysis of Immunomodulation in Head and Neck Squamous Cell CarcinomaView all articles

Pathological Regression Patterns Following Neoadjuvant Chemo-immunotherapy in Head and Neck Squamous Cell Carcinoma: A Pilot Study

Provisionally accepted
Dikan WangDikan Wang1,2Fanning ZengFanning Zeng1,2Sien ZhangSien Zhang1,2Wan-Ming HuWan-Ming Hu3Yahui WangYahui Wang1,2Daiqiao OuyangDaiqiao Ouyang1,3滨 曾滨 曾1,2Guozhong ZengGuozhong Zeng1,2Jingyuan LiJingyuan Li1,2*Guiqing LiaoGuiqing Liao1,2*Yujie LiangYujie Liang1,2*
  • 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, GuangZhou, China
  • 2Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, GuangZhou, China
  • 3Department of Pathology,State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China

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regression after NACI in HNSCC. Hence, our data presumably supports a reduced surgical extent in post-NACI HNSCC patients. Future studies should focus on identifying accurate predictive factors for the regression pattern, which may eventually assist in risk stratification and surgical decision making.The pattern of tumor pathological regression after NACI for HNSCC is mainly divided into centripetal and non-centripetal regression, with the former accounting for the major portion of the regression.

Keywords: Chemo-immunotherapy, Neoadjuvant Therapy, Head and neck squamous cell carcinoma (HNSCC), Regression pattern, Pathological response

Received: 12 May 2025; Accepted: 14 Jul 2025.

Copyright: © 2025 Wang, Zeng, Zhang, Hu, Wang, Ouyang, 曾, Zeng, Li, Liao and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Jingyuan Li, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, GuangZhou, China
Guiqing Liao, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, GuangZhou, China
Yujie Liang, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, GuangZhou, China

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