CASE REPORT article
Front. Immunol.
Sec. Primary Immunodeficiencies
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1629876
This article is part of the Research TopicSecondary Antibody DeficiencyView all 3 articles
Case Report: A simple case of drug induced secondary antibody deficiency or a rare primary immune deficiency?
Provisionally accepted
- 1North Bristol NHS Trust, Bristol, United Kingdom
- 2Royal United, Bath, United Kingdom
- 3Royal United Hospital, Bath, United Kingdom
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Antibody deficiency may be primary because of an underlying inborn error of immunity, or secondary, due to another disease process or medication, leading to decreased antibody production or increased antibody loss. Secondary antibody deficiency is much more common than primary. It can however be difficult to distinguish primary from secondary, and both should be considered when assessing patients with hypogammaglobulinaemia. The case presented highlights the importance of confirming the underlying pathophysiology in patients presenting with antibody deficiency, the contribution of genetic assessment to the care of patients with complex phenotypes, and the impact this can have on long-term patient management.
Keywords: Antibody deficiency, primary, secondary, valproate-induced, inborn error ofimmunity, cardiomyopathy, Roifman syndrome
Received: 16 May 2025; Accepted: 21 Oct 2025.
Copyright: © 2025 Johnston, Evans, Berry and Watkinson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sarah Louise Johnston, sarah.johnston@nbt.nhs.uk
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