REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1630410
This article is part of the Research TopicExploring Cardiovascular and Cerebrovascular Diseases Interaction with Inflammation: Biomarkers, Drug Targets, and Personalized Treatments through Multi-omics Data Integration, Volume IIView all articles
The alarmin tandem: unraveling the complex effect of S100A8/A9from atherosclerosis to cardiac arrhythmias
Provisionally accepted
- 1Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures, Romania
- 2George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mures, Romania
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Introduction: Inflammation plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs), particularly in heart failure (HF), cardiac arrhythmias, and atherosclerotic cardiovascular disease (ASCVD). The calcium-binding proteins S100A8 and S100A9, primarily functioning as a heterodimer (S100A8/A9), have emerged as essential mediators in cardiovascular pathophysiology through the toll-like receptor 4 (TLR-4) and receptor for advanced glycation end-products (RAGE) signaling pathway. This review aims to comprehensively explore the role of S100A8/A9 in ASCVD, HF, and cardiac arrhythmogenesis, and to discuss its pathophysiological implications, clinical significance, and potential utility as a novel therapeutic target.In ASCVD, S100A8/A9 promotes endothelial dysfunction and facilitates monocyte recruitment and foam cell formation. The heterodimer amplifies vascular inflammation via TLR4 and
Keywords: arrhythmias, Atherosclerosis, Inflammation, S100A8/A9, Heart Failure
Received: 17 May 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Cozac, Halațiu and Scridon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Alina Scridon, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mures, Romania
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.