REVIEW article
Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1632677
Participants in Treponema pallidum pathogenesis: progress in functional proteins
Provisionally accepted
- 南华大学附属第二医院, 湖南，衡阳, China
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Treponema pallidum subsp. pallidum (T. pallidum) is the causative agent of syphilis, a chronic sexually transmitted disease that leads to widespread organ damage. The pathogenesis of syphilis involves crucial functional proteins that facilitate bacterial adhesion to host cells, invasion, dissemination, immune evasion, and inflammatory responses. Investigating these proteins is crucial for the development of innovative diagnostic tools, vaccines, and therapies. However, the intricate nature of T. pallidum and the inability to culture in vitro hinder our comprehensive undestanding of these proteins. This review article presents innovative understandings of the pathogenesis of T. pallidum functional proteins, building upon existing knowledge. This paper establishes a foundation for comprehending the current knowledge landscape and outlining future research avenues.
Keywords: Treponema pallidum, Functional protein, Interaction, Pathogenesis, Immune Evasion
Received: 21 May 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 Zuo, Xiao, Xiang, Xi E and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yongjian Xiao, 南华大学附属第二医院, 湖南，衡阳, China
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