REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1634688
This article is part of the Research TopicEndothelium, Innate Immunity and Coagulation in Hematological DisordersView all 19 articles
Cancer treatment-induced thrombocytopenia(CTIT) : Diagnosis,Mechanisms and Management
Provisionally accepted
- First Affiliated Hospital, Dalian Medical University, Dalian, China
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Cancer treatment-induced thrombocytopenia(CTIT) is a common adverse effect in malignant tumor patients, significantly increasing the risk of bleeding and negatively impacting treatment efficacy and quality of life.Current treatment options for CTIT primarily include platelet transfusion, recombinant human interleukin-11(rhIL-11),recombinant human thrombopoietin(rhTPO) and thrombopoietin receptor agonists(TPO-RAs).However, these methods have their limitations; for instance, platelet transfusions may cause adverse reactions, and the efficacy and safety of rhTPO and TPO-RAs remain controversial.This review aims to summarize the current treatment landscape for CTIT and explore new therapeutic advancement, including the potential role of traditional Chinese medicine, in order to provide more effective treatment strategies for clinical practice.
Keywords: CTIT, chemotherapy-induced thrombocytopenia(CIT), immune checkpointinhibitors-induced thrombocytopenia(ICIIT), TPO-RAs, Traditional Chinese Medicine(TCM)
Received: 25 May 2025; Accepted: 03 Sep 2025.
Copyright: © 2025 Zhao, Shan, Sui, Song, Cheng and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Zhao, First Affiliated Hospital, Dalian Medical University, Dalian, China
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