CASE REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1636575
Lymphoepithelioma-like Carcinoma with Carcinosarcoma of the Endometrium: A Case Report and Literature Review
Provisionally accepted
- 1The First people's Hospital of Xiaoshan District, Hangzhou, China
- 2Chengxiang Health Service Center, Xiaoshan District, Hangzhou, China
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This report describes a 56-year-old female diagnosed with lymphoepithelioma-like carcinoma with carcinosarcoma of the endometrium (LELCCSE). She experienced vaginal bleeding and lower abdominal discomfort without any obvious cause following six years of menopause. She sought treatment at our hospital in Hangzhou,China. An ultrasound examination revealed a hypoechoic mass within the uterus. Subsequently, a biopsy confirmed it as lymphoepithelioma-like carcinoma (LELC) with carcinosarcoma.The patient underwent a total hysterectomy, bilateral salpingo-oophorectomy, and associated lymphadenectomy. The postoperative pathology suggested LELC complicated with carcinosarcoma and an IIC grade by the 2023 FIGO staging system. She received adjuvant chemotherapy and radiotherapy without any molecular testing due to her financial constraints. A gene which encodes the catalytic subunit of DNA polymerase epsilon(POLE) mutation was found by the retrospective molecular testing; however, no recurrence or metastasis occurred after 12 follow-up months.
Keywords: Carcinosarcoma, Clinicopathology, Endometrium, Lymphoepithelioma-like carcinoma, Molecular pathology
Received: 28 May 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Xu, Huang, Zhu and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Huang, The First people's Hospital of Xiaoshan District, Hangzhou, China
Jianping Shi, The First people's Hospital of Xiaoshan District, Hangzhou, China
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