ORIGINAL RESEARCH article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1637232
PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism
Provisionally accepted
- Changhai Hospital, Second Military Medical University, Shanghai, China
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Lack of clinical treatment for impaired fracture healing Due to the complexity of the fracture healing process. Osteoclasts, formed by monocytes, play a key role in the fracture healing process. However, there is still a lack of effective clinical tools to promote fracture healing by regulating osteoclasts due to their complex function in bone tissue reconstruction. Our study revealed that Protein Arginine Methyltransferase 6 (PRMT6) is involved in fracture healing by modulating osteoclast glucose metabolism.The present study found that PRMT6 promotes osteoclastogenesis and activates glycolysis. In contrast, PRMT6 deficiency or inhibition reversed this phenomenon.Further, we demonstrated that PRMT6 inhibitors can effectively promote fracture healing by inhibiting osteoclast formation. Our work provides new ideas for clinical treatment of impaired fracture healing. Meanwhile, our work provides new clues for understanding bone tissue regeneration.
Keywords: PRMT6, Fracture Healing, Osteoclasts, Glycolysis, EPZ020411
Received: 29 May 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Nan, Wang, Nian, ZHANG, Zhou and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Tang, Changhai Hospital, Second Military Medical University, Shanghai, China
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