ORIGINAL RESEARCH article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1638710
This article is part of the Research TopicImmune regulatory networks in the skin during normal and aberrant immunological responses: mechanisms, modulation, and therapeutic targetsView all 3 articles
Scalp Seborrheic Dermatitis Demonstrates a Skewing of Th1 Activation: A Proteomic Study in Lesional Skin
Provisionally accepted
- Dermatology Hospital of Zhejiang Province, Huzhou, China
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Scalp seborrheic dermatitis (SSD) is a common, chronic inflammatory skin disease. Its pathogenesis and immunological features have been poorly studied. To elucidate the molecular profile of adult patients with SSD using punch biopsies, we assessed 92 inflammatory biomarkers in the lesional scalps of SSD patients (n=16) and demographically matched healthy controls (HCs; n=12) using Olink high-throughput proteomics. We identified 16 differentially expressed proteins (DEPs) between lesional scalps of patients with SSD and those of HCs. SSD lesional scalps demonstrated significantly greater expressions of proteins related to T-cell/lymphocyte activation, the cytokine storm signaling pathway and the CGAS-STING signaling pathway. Ingenuity pathway analysis (IPA) highlighted Th1 skewing. These data suggest that SSD is associated with Th1 skewing and the dysregulation of lipid metabolism. These analyses provide a rationale for novel treatment approaches for SSD patients, mainly those targeting Th1 pathways.
Keywords: Inflammatory, Olink, proteomic, Scalp, Seborrheic dermatitis
Received: 31 May 2025; Accepted: 12 Sep 2025.
Copyright: © 2025 Shen, Chen, Hu, Huang and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiang Dong, qiangdong.edu@outlook.com
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