EDITORIAL article

Front. Immunol.

Sec. Viral Immunology

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1639948

This article is part of the Research TopicViral Impact on CNS: Mechanisms of Immune Dysfunction and Cognitive DeclineView all 10 articles

Editorial: Viral Impact on the CNS -Mechanisms of Immune Dysfunction and Cognitive Decline

Provisionally accepted
  • 1RMIT University, Melbourne, Australia
  • 2The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
  • 3Burnet Institute, Melbourne, Australia
  • 4The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, United States
  • 5Department of Microbiology and Immunology, University of Western Ontario, London, Canada
  • 6Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, United States
  • 7St Vincent's Hospital Sydney, Darlinghurst, Australia
  • 8University of New South Wales, Sydney, Australia
  • 9Monash University, Melbourne, Australia

The final, formatted version of the article will be published soon.

Recently, the contribution of viruses to neuropathology and cognitive decline has garnered significant 26 interest with viral infection at least in part, with pathogenesis of dementia, multiple 27 sclerosis and virus-specific cognitive impairment (1)(2)(3)(4). Neuropathology can occur during acute, 28 chronic and latent infection and, in some cases, even in the presence of antiviral therapy. However, the 29 precise mechanisms by which specific viruses induce neuropathology and cognitive dysfunction 30 remain unclear. This underscores the need to elucidate the underlying processes in order to develop 31 effective therapeutic strategies. In this Research Topic, we have collated a series of manuscripts that 32 assess the contribution of various viruses including Human Immunodeficiency Virus (HIV), SARS-33CoV-2, and others, to neuroinflammation, neuropathology and cognitive disorders. 34As mentioned above, the role of viruses in neuroinflammation and neuropathology has gained 36 significant attention in recent years.

Keywords: Brain, Viruses, Neuroinflammation, Neuropathology, Cognition

Received: 03 Jun 2025; Accepted: 04 Jun 2025.

Copyright: © 2025 Angelovich, Mediouni, Klein, Estes, Brew and Churchill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Melissa Jayne Churchill, RMIT University, Melbourne, Australia

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