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REVIEW article

Front. Immunol.

Sec. T Cell Biology

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1640113

This article is part of the Research TopicT Regulatory Cells: Mechanisms and Therapeutical AdvancesView all articles

The Emerging Role of Tissue Regulatory T Cells in Tissue Repair and Regeneration

Provisionally accepted
Abdul RaheemAbdul Raheem1Ilyas KhanIlyas Khan2Iqbal AhmadIqbal Ahmad2Abdul WajidAbdul Wajid3Mohammad Y AlshahraniMohammad Y Alshahrani4Fuad M AlzahraniFuad M Alzahrani5Khalid AlzahraniKhalid Alzahrani5Abdul QadeerAbdul Qadeer6*I-Chuang LiaoI-Chuang Liao7*Chien-Chin ChenChien-Chin Chen8*
  • 1College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Wuhan, China
  • 2Chinese Academy of Agricultural Sciences Harbin Veterinary Research Institute, Harbin, China
  • 3Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Khyber Pukhtunkhwa, Pakistan, Dera Ismail Khan, Pakistan
  • 4Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia., Abha, Saudi Arabia
  • 5Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia, Taif, Saudi Arabia
  • 6School of Life Science, Central South University, Changsha, China
  • 7School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Kaohsiung, Taiwan
  • 8Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan

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Regulatory T cells (Tregs) are a unique subset of T cells vital for maintaining immune balance, preventing autoimmune diseases, and controlling immune responses. First identified in the early 1990s, Tregs are now well recognized for their role in suppressing excessive immune reactions and promoting tolerance to the body's tissues. Among the broader Treg population, Tissue regulatory T cells (Tissue Tregs) are distinct as they do more than suppress immunity; they actively contribute to tissue repair and regeneration. Studies in both mice and humans have highlighted the important role of in aiding tissue repair and maintaining tissue integrity. Recent research reveals that Tregs participate in wound healing and tissue regeneration across various organs, including the heart, liver, kidneys, muscles, lungs, bones, and central nervous system. These discoveries emphasize the wide-ranging and significant influence of Tregs in fostering recovery and healing in different tissues throughout the body. These cells are characterized by their ability to produce a variety of growth factors, cytokines, and signaling molecules that support the repair and regeneration of damaged tissues. In this review, we present an overview of the emerging understanding of Treg-mediated repair processes in damaged tissues and organs.

Keywords: regulatory T cells, tissue, injury, repair, Regeneration

Received: 03 Jun 2025; Accepted: 15 Aug 2025.

Copyright: © 2025 Raheem, Khan, Ahmad, Wajid, Alshahrani, Alzahrani, Alzahrani, Qadeer, Liao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Abdul Qadeer, School of Life Science, Central South University, Changsha, China
I-Chuang Liao, School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Kaohsiung, Taiwan
Chien-Chin Chen, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material