ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1640224
This article is part of the Research TopicTumor Microenvironment: Inflammation and Immune Signal Transduction at Single-Cell ResolutionView all 9 articles
Exploring Research Trends in Cancer Immunotherapy via Single-Cell Technologies: A Scientometric Perspective
Provisionally accepted
Zhongxun Li1,2*
Han Qi1,2
Zimu Huang3
Sen Zhang4
Huina Guo1,2
Liu Hongliang1,2,5
Guan Xiaoya1,2Hairong Li6Chunming Zhang1,2,4- 1Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
- 2Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
- 3Shanxi Medical University, Taiyuan, China
- 4Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, China
- 5Department of Cell Biology and Genetics, the Basic Medical School of Shanxi Medical University, Taiyuan, China
- 6Department of Histology and Embryology of Shanxi Medical University, Taiyuan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Introduction: Cancer immunotherapy has brought new therapeutic hopes for cancer patients, but it is complex in its mechanism of action, and there are significant individual differences, which restricts its wide use. As single-cell analysis technology develops rapidly, it provides an innovative research approach to investigate immunotherapy mechanisms, to identify potential biomarkers, and to optimize individualized treatment strategies.The Core Collection of Web of Science (WOSCC) was used to retrieve and obtain relevant literature related to "application of single cell sequencing in cancer immunotherapy" since the establishment of the WOSCC. A quantitative analysis and visualization of the related literature was conducted using tools such as Bibliometrix, Excel, CiteSpace, VOSviewer, and Scimago Graphica.The total number of related literatures included was 4856, with an average annual growth rate of 25.14%. According to published articles, China and the United States lead the field. Frontiers in immunology, Nature Communications, Journal for Immunotherapy of Cancer, Scientific Reports, Frontiers in Oncology and Cancers have an important academic influence in this field. Research hotspots focus on tumor immune microenvironment and cellular heterogeneity. Research trends such as spatial transcriptomics, standardized processes, and T cell function are becoming increasingly popular.In tumor immunotherapy, single-cell sequencing is profoundly changing the research paradigm. It not only improves our understanding of the immune microenvironment and therapeutic heterogeneity, but also assists us in identifying accurate markers and formulating individualized treatment plans.
Keywords: Immunotherapy, Tumor immune microenvironment, heterogeneity, single-cell RNA sequencing, Bibliometrix
Received: 03 Jun 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Li, Qi, Huang, Zhang, Guo, Hongliang, Xiaoya, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhongxun Li, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.