Abstract
Gastric cancer, a leading global cause of cancer-related mortality, is frequently diagnosed at advanced stages with peritoneal metastasis, significantly limiting curative options. Current strategies integrate systemic chemotherapy, hyperthermic intraperitoneal chemotherapy (HIPEC), and targeted therapies, yet outcomes remain suboptimal. Claudin18.2, a tight junction protein overexpressed in 27.4–52% of gastric cancers, has emerged as a novel therapeutic target, with recent Phase III trials demonstrating survival benefits for Claudin18.2-targeted monoclonal antibodies in HER2-negative advanced disease. However, the synergy of HIPEC with Claudin18.2-targeted therapies remains unexplored. This study presents a case of Claudin18.2-positive advanced gastric adenocarcinoma with peritoneal metastasis treated with a multimodal regimen: HIPEC, systemic CapeOx chemotherapy, and Claudin18.2-targeted therapy (ASKB589). Following 12 cycles, imaging and tumor markers (CA125, CEA) normalized, enabling curative gastrectomy. At 893 days post-diagnosis, the patient remains disease-free (PFS/DFS: 893/573 days) on adjuvant capecitabine. Treatment-related toxicities (predominantly Grade 1–3 hematologic and gastrointestinal events) were manageable. This case highlights Claudin18.2 as an actionable biomarker and proposes a “local-systemic” synergy model for peritoneal-metastatic gastric cancer. However, the absence of cytoreductive surgery and single-case limitations necessitate validation through randomized trials. Future research should prioritize biomarker-driven HIPEC protocols (e.g., nanoparticle-enhanced Claudin18.2-targeted delivery) and dynamic monitoring of Claudin18.2 expression during therapy.
Introduction
Gastric cancer is a common malignant tumor with a poor prognosis, ranking as the fifth most prevalent cancer and the fifth leading cause of cancer-related mortality globally (, ). Surgery is currently regarded as the sole curative treatment (). However, most patients are diagnosed at advanced stages, missing the optimal window for surgical intervention. Approximately 50% of advanced gastric cancer cases with distant metastasis involve peritoneal dissemination, which clinically manifests as hepatogenic pain, ascites, and other symptoms (). The primary therapeutic strategies for advanced gastric cancer include comprehensive regimens combining neoadjuvant chemoradiotherapy, molecular targeted therapy, and immunotherapy (). For patients with peritoneal metastasis, current approaches involve preoperative neoadjuvant intraperitoneal and systemic combination chemotherapy, hyperthermic HIPEC combined with cytoreductive surgery, and multimodal therapies integrating intraperitoneal, intravenous, and oral administration (). Intraperitoneal perfusion therapy, which combines hyperthermia and chemotherapy, enhances tumor cell sensitivity to chemotherapeutic agents, increases local drug concentration, and reduces systemic adverse effects (). As peritoneal metastasis represents a localized manifestation of systemic disease, systemic chemotherapy remains the cornerstone of treatment, with intraperitoneal chemotherapy serving as an adjunct (). Claudin18.2, a highly selective tight junction protein, is normally expressed exclusively in differentiated gastric mucosal epithelial cells but is retained during malignant transformation. It is expressed in a significant proportion of primary gastric cancers and their metastases, emerging as a promising therapeutic target following HER2 (). The reported positivity rates for Claudin18.2, defined by moderate-to-strong immunohistochemical (IHC) expression, vary between 27.4% and 52% across studies due to differences in IHC methodologies, positivity thresholds, and patient populations (–). This prevalence markedly exceeds that of HER2, positioning Claudin18.2 as a potential biomarker for targeted therapy, tumor diagnosis, treatment efficacy evaluation, and prognosis prediction. To date, no relevant domestic or international literature has reportedxon the combination of HIPEC with Claudin18.2-targeted therapy for Claudin18.2-positive gastric cancer patients with peritoneal metastasis. Herein, we present a case of HIPEC followed by Claudin18.2-targeted therapy combined with CapeOx chemotherapy, which achieved complete resolution of peritoneal metastases and enabled curative resection, accompanied by a literature review.
Case presentation
A 39-year-old male presented with a 10-day history of right lower quadrant abdominal pain and was admitted on December 6, 2022. He denied a history of hypertension, diabetes, or cardiovascular disease, as well as a family history of cancer. Eight months prior, the patient experienced right lower quadrant pain of unknown etiology and was diagnosed with acute appendicitis at a local hospital, which resolved after one week of antibiotic therapy. One month before admission, he underwent gastroscopy revealing gastric ulcer and chronic non-atrophic gastritis, treated symptomatically with acid suppression without further investigation. Ten days prior to admission, the pain recurred and failed conservative management. Abdominal non-contrast CT (from the diaphragmatic dome to the pelvic inlet) demonstrated a thickened appendix with intraluminal fecalith, adjacent mesenteric exudate, lymphadenopathy, and signs of peritonitis, suggestive of acute appendicitis. Tumor screening via contrast-enhanced CT was recommended (Figure 1). Diagnostic laparoscopy on December 8, 2022, revealed moderate ascites and widespread peritoneal and omental tumor nodules, consistent with metastatic malignancy (Supplementary Figure S1). Four HIPEC catheters were placed at the bilateral subcostal midclavicular lines and McBurney’s points. Postoperative pathology of the omental biopsy confirmed poorly differentiated adenocarcinoma (Supplementary Figure S2). IHC showed positivity for pan-CK and CK8/18, negativity for HER2, and a high proliferation index (Ki-67 ~80%). Ascitic cytology revealed severe nuclear atypia (Supplementary Figure S2). Subsequent gastroscopy identified a raised, ulcerated lesion on the greater curvature of the stomach (Supplementary Figure S3). Biopsy confirmed poorly differentiated adenocarcinoma with marked nuclear atypia, IHC positivity for CKpan and CK8/18, HER2 negativity (0), and a Ki-67 index of 80%. The final diagnosis was gastric adenocarcinoma (cT4aN2M1) with peritoneal metastasis. Karnofsky performance status (KPS) was 80, ECOG score 1, VAS score 2, and NRS score 2. IHC further revealed moderate Claudin18.2 expression (3+ [strong] in 10%, 2+ [moderate] in 30%, 1+ [weak] in 50%, and negative in 10%) and PD-L1 negativity (TPS <1%; CPS = 2) (Supplementary Figure S2). It fulfills the inclusion criteria pertaining to moderate-high Claudin18.2 expression levels for the ASKB589 Injection clinical trial. This testing was performed as an Laboratory Developed Test assay at the central laboratory of Medx Translation Medicine Research (Suzhou) Co., Ltd., using the Claudin 18.2 antibody reagent (immunohistochemistry) kit manufactured by Medx (Catalog No.: P054B01.a), with staining results interpreted based on a percentage threshold.
Figure 1
A multidisciplinary team recommended HIPEC combined with Claudin18.2-targeted therapy (ASKB589, 6 mg/kg every 3 weeks) and systemic chemotherapy. HIPEC involved 4500 mL perfusate at 43°C for 60 minutes (flow rate: 500 mL/min). Six cycles of CapeOx (oxaliplatin 130 mg/m² on Day 1; capecitabine 1000 mg/m² twice daily on Days 1–14, every 3 weeks) were administered, followed by six cycles of capecitabine monotherapy. Post-treatment CT and gastroscopy demonstrated partial response with reduced gastric wall thickening (Figure 2). Tumor markers (CA125, CEA) normalized by February 20, 2023. Transient hyperbilirubinemia and hypoalbuminemia resolved postoperatively (Figure 3). During the entire treatment course, the patient experienced a total of 41 adverse events, predominantly hematologic toxicities and gastrointestinal reactions. Hematologic toxicities included neutropenia (4 events, with 1 Grade 3 occurrence), thrombocytopenia (3 events), leukopenia (3 events), and anemia (1 event). Gastrointestinal reactions were most frequently observed as vomiting (11 Grade 1 events) and nausea (7 Grade 1 events). Other abnormalities included occult blood positivity in urine and stool (2 events each) and mild elevations in liver function indices (1 event each for bilirubin and aspartate aminotransferase [AST]). No Grade 4 events were reported, and only 1 Grade 3 neutropenia event occurred. All other events were Grade 1–2 and resolved with supportive care. Overall, the treatment demonstrated manageable safety, though close monitoring for myelosuppression remained warranted. (Table 1).
Figure 2
Figure 3
Table 1
| Adverse Event | Any grade (n=41) | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|---|
| Any adverse event | 41 | 32 | 4 | 1 | 0 |
| Vomiting | 11 | 11 | – | – | – |
| Nausea | 7 | 7 | – | – | – |
| Abdominal pain | 2 | 2 | – | – | – |
| Gastric retention | 1 | 1 | – | – | – |
| Constipation | 1 | 1 | – | – | – |
| Positive urine occult blood | 2 | – | – | – | – |
| Positive fecal occult blood | 2 | – | – | – | – |
| Leukopenia | 3 | 2 | 1 | – | – |
| Neutropenia | 4 | 1 | 2 | 1 | – |
| Lymphopenia | 1 | 1 | – | – | – |
| Anemia | 1 | 1 | – | – | – |
| Thrombocytopenia | 3 | 2 | 1 | – | – |
| Hyperbilirubinemia | 1 | 1 | – | – | – |
| Elevated AST | 2 | 2 | – | – | – |
Adverse events during treatment and grading.
Following tumor diagnosis on December 8, 2022, the patient underwent four cycles of HIPEC, 12 cycles of systemic therapy (6 cycles of CapeOx regimen [oxaliplatin + capecitabine] and 6 cycles of capecitabine monotherapy), and 12 cycles of Claudin18.2-targeted therapy. After completing 12 treatment cycles, successful conversion therapy enabled curative gastrectomy on October 24, 2023 (Figure 2). Postoperative histopathology revealed poorly differentiated gastric adenocarcinoma with treatment-related fibrotic and histiocytic reactions. According to NCCN guidelines, the tumor regression grade (TRG) was assessed as Grade 3, resulting in a final pathological stage of pT3N1M0. Omental specimens demonstrated foamy histiocyte proliferation, multinucleated giant cell reactions, and treatment-induced changes, with no residual carcinoma identified. Postoperative contrast-enhanced CT confirmed successful total gastrectomy with patent anastomosis and no significant wall thickening or abnormal enhancement at the anastomotic site. The patient has remained alive with adjuvant capecitabine maintenance therapy, achieving an overall survival (OS) and progression-free survival (PFS) of 893 days and a disease-free survival (DFS) of 573 days as of May 19, 2025.
Discussion and conclusion
Gastric cancer, a malignancy with poor prognosis, is often diagnosed at advanced stages, leaving many patients ineligible for curative surgery. Peritoneal metastasis, a common complication in advanced gastric cancer, predominantly manifests as malignant ascites or intestinal obstruction (, ). Current therapeutic strategies for metastatic gastric cancer emphasize systemic pharmacotherapy, including chemotherapy, molecular-targeted agents, and immune checkpoint inhibitors (). Clinically validated biomarkers for targeted therapy selection in advanced gastric/gastroesophageal junction cancer are limited to HER2 positivity, microsatellite instability (MSI) status, and PD-L1 expression (). Emerging biomarkers under investigation include FGFR2 amplification/overexpression, MET amplification, Claudin18.2 (Claudin18.2) overexpression, and Epstein-Barr virus (EBV) association (). HER2, expressed in 7.3%–20.2% of gastric cancers, remains a key therapeutic target, with trastuzumab combined with chemotherapy established as the first-line standard for HER2-positive disease (, ).
Claudin18.2, a tight junction protein overexpressed in 27.4%–52% of gastric cancers, has emerged as a promising biomarker and therapeutic target; While its expression varies across studies due to differences in immunohistochemical (IHC) methodologies and thresholds, its stability and selectivity support its potential role in diagnosis, treatment response assessment, and prognosis prediction (–, ). Current Claudin18.2-targeted therapies under clinical evaluation include monoclonal antibodies (e.g., zolbetuximab), bispecific antibodies, CAR-T cells, and antibody-drug conjugates (ADCs). Phase III trials such as GLOW (NCT03653507) and SPOTLIGHT demonstrated significant improvements in progression-free survival (PFS) and overall survival (OS) with zolbetuximab combined with CAPOX or mFOLFOX6 versus chemotherapy alone in Claudin18.2-positive, HER2-negative advanced gastric/GEJ cancer (, ). Notably, the 2023 CSCO guidelines now recommend Claudin18.2 IHC testing (Category 2B, Level II evidence) (). While systemic chemotherapy faces limitations in penetrating the blood-peritoneal barrier, HIPEC enhances local drug concentration and efficacy. In this case, HIPEC followed by CapeOx chemotherapy and claudin18.2-targeted therapy (ASKB589) achieved regression of peritoneal metastases and tumor downstaging, which enabled a curative resection. Potential synergistic mechanisms include HIPEC-mediated eradication of free peritoneal tumor cells, systemic chemotherapy targeting micrometastases, and Claudin18.2-targeted antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) (). Preclinical studies suggest chemotherapeutics like oxaliplatin may upregulate Claudin18.2 expression and enhance immunogenic cell death, further potentiating targeted therapy (–) (Figure 4).
Figure 4
This case has several inherent limitations, including the absence of cytoreductive surgery combined with HIPEC-chemotherapy, the lack of dynamic monitoring of CLDN18.2 expression during treatment, and—notably—the fact that targeted therapy was based solely on biopsy results from the primary lesion, without tissue sampling from peritoneal metastases. The latter point is particularly relevant in light of recent data published by Saito et al., which revealed that CLDN18.2 expression in peritoneal metastases is often significantly lower than in primary tumors (). Therefore, the remarkable efficacy observed in this patient should be interpreted with caution, as it may reflect unique tumor biology rather than generalizable treatment effects. To address these gaps, future studies should incorporate both planned repeat biopsies to elucidate therapy-induced modulation of CLDN18.2 expression and synchronous CLDN18.2 analysis of paired primary and metastatic sites—especially peritoneal metastases—in order to clarify heterogeneity patterns, determine the optimal biopsy site for treatment guidance, and ultimately optimize therapeutic sequencing to overcome resistance. Larger randomized trials will be essential to validate this multimodal approach.
Statements
Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Ethics statement
The studies involving humans were approved by the Medical Ethics Committee of Beijing Cancer Hospital. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Author contributions
WL: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing. XDH: Data curation, Formal Analysis, Investigation, Writing – original draft, Writing – review & editing. XWH: Data curation, Formal Analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing. JZ: Data curation, Formal Analysis, Writing – review & editing. BM: Data curation, Formal Analysis, Writing – review & editing. ZY: Data curation, Formal Analysis, Writing – review & editing. YW: Supervision, Visualization, Writing – review & editing. LG: Validation, Visualization, Writing – review & editing. JS: Validation, Visualization, Writing – review & editing. HC: Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing.
Funding
The author(s) declare that financial support was received for the research and/or publication of this article. This research was supported by National Natural Science Foundation of China (82473266, 82160129), Key Project of Science and Technology in Gansu province (22ZD6FA054), Major scientific research project for scientific and technological innovation in the health industry of Gansu Province (GSWSZD-2024-17), General Project of Gansu Province Joint Research Fund (24JRRA929), Key Talents Project of Gansu Province (2019RCXM020), Science and Technology Project of Chengguan District of Lanzhou City (2020SHFZ0039, 2020JSCX0073), Medical Research Innovation Ability Improvement Project of Lanzhou University (lzuyxcx-2022-160), Excellent Textbook Cultivation Project of Lanzhou University (lzuyxcx-2022-45), Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital (CY2023-ZD-01).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Generative AI statement
The author(s) declare that no Generative AI was used in the creation of this manuscript.
Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1641424/full#supplementary-material
Supplementary Figure 1Laparoscopic findings showing widespread peritoneal and omental tumor nodules, indicative of malignant peritoneal metastasis.
Supplementary Figure 2Pathological examination results. (A) Omental biopsy: Poorly differentiated adenocarcinoma within fibrous and lymphoid tissue. (B) Ascitic fluid cytology: Severely dysplastic cells. (C) Gastric biopsy: Loss of glandular architecture with fibrotic stroma and diffusely arranged atypical epithelial cells exhibiting hyperchromatic nuclei. Immunohistochemistry revealed Claudin18.2 tumor staining intensity: 3+ (10%), 2+ (30%), 1+ (50%), and negative (10%); PD-L1 negativity (TPS <1%, CPS = 2).
Supplementary Figure 3Endoscopic progression of the gastric lesion. (A) Baseline diagnosis; (B) After 4 cycles of HIPEC; (C–H) Sequential endoscopic findings post-Cycle 2 (C2) through Cycle 12 (C12).
References
1
BrayFLaversanneMSungHFerlayJSiegelRLSoerjomataramIet al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin. (2024) 74:229–63. doi: 10.3322/caac.21834
2
SungHFerlayJSiegelRLLaversanneMSoerjomataramIJemalAet al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin. (2021) 71:209–49. doi: 10.3322/caac.21660
3
LiGZDohertyGMWangJ. Surgical management of gastric cancer: A review. JAMA surgery. (2022) 157:446–54. doi: 10.1001/jamasurg.2022.0182
4
SongZWuYYangJYangDFangX. Progress in the treatment of advanced gastric cancer. Tumour biology: J Int Soc Oncodevelopmental Biol Med. (2017) 39:1010428317714626. doi: 10.1177/1010428317714626
5
ZhangWHHuJK. Current status of diagnosis and treatment of gastric cancer peritoneal metastasis. Zhonghua wei chang wai ke za zhi = Chin J gastrointestinal surgery. (2021) 24:204–7. doi: 10.3760/cma.j.cn.441530-20201116-00611
6
RauBLangHKoenigsrainerAGockelIRauHGSeeligerHet al. Effect of hyperthermic intraperitoneal chemotherapy on cytoreductive surgery in gastric cancer with synchronous peritoneal metastases: the phase III GASTRIPEC-I trial. J Clin Oncol Off J Am Soc Clin Oncol. (2024) 42:146–56. doi: 10.1200/JCO.22.02867
7
YuPYeZDaiGZhangYHuangLDuYet al. Neoadjuvant systemic and hyperthermic intraperitoneal chemotherapy combined with cytoreductive surgery for gastric cancer patients with limited peritoneal metastasis: a prospective cohort study. BMC cancer. (2020) 20:1108. doi: 10.1186/s12885-020-07601-x
8
SinghPToomSHuangY. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer. J Hematol Oncol. (2017) 10:105. doi: 10.1186/s13045-017-0473-4
9
ShahMAShitaraKAjaniJABangYJEnzingerPIlsonDet al. Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial. Nat Med. (2023) 29:2133–41. doi: 10.1038/s41591-023-02465-7
10
SahinUTüreciÖManikhasGLordickFRusynAVynnychenkoIet al. FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma. Ann Oncol Off J Eur Soc Med Oncol. (2021) 32:609–19. doi: 10.1016/j.annonc.2021.02.005
11
RohdeCYamaguchiRMukhinaSSahinUItohKTüreciÖ. Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma. Jpn J Clin Oncol. (2019) 49:870–6. doi: 10.1093/jjco/hyz068
12
BaekJHParkDJKimGYCheonJKangBWChaHJet al. Clinical implications of claudin18.2 expression in patients with gastric cancer. Anticancer Res. (2019) 39:6973–9. doi: 10.21873/anticanres.13919
13
CaoWXingHLiYTianWSongYJiangZet al. Claudin18.2 is a novel molecular biomarker for tumor-targeted immunotherapy. biomark Res. (2022) 10:38. doi: 10.1186/s40364-022-00385-1
14
LiZWangJWangZXuY. Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions. EBioMedicine. (2023) 92:104601. doi: 10.1016/j.ebiom.2023.104601
15
ThomassenIvan GestelYRvan RamshorstBLuyerMDBosschaKNienhuijsSWet al. Peritoneal carcinomatosis of gastric origin: a population-based study on incidence, survival and risk factors. Int J cancer. (2014) 134:622–8. doi: 10.1002/ijc.28373
16
AjaniJAD'AmicoTABentremDJChaoJCookeDCorveraCet al. Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Network: JNCCN. (2022) 20:167–92. doi: 10.6004/jnccn.2022.0008
17
NakamuraYKawazoeALordickFJanjigianYYShitaraK. Biomarker-targeted therapies for advanced-stage gastric and gastro-oesophageal junction cancers: an emerging paradigm. Nat Rev Clin Oncol. (2021) 18:473–87. doi: 10.1038/s41571-021-00492-2
18
LordickFCarneiroFCascinuSFleitasTHaustermansKPiessenGet al. Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. (2022) 33:1005–20. doi: 10.1016/j.annonc.2022.07.004
19
ZhuYZhuXWeiXTangCZhangW. HER2-targeted therapies in gastric cancer. Biochim Biophys Acta Rev cancer. (2021) 1876:188549. doi: 10.1016/j.bbcan.2021.188549
20
ShahMAKennedyEBAlarcon-RozasAEAlcindorTBartleyANMalowanyABet al. Immunotherapy and targeted therapy for advanced gastroesophageal cancer: ASCO guideline. J Clin Oncol Off J Am Soc Clin Oncol. (2023) 41:1470–91. doi: 10.1200/JCO.22.02331
21
KyunoDTakasawaATakasawaKOnoYAoyamaTMagaraKet al. Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials. Tissue barriers. (2022) 10:1967080. doi: 10.1080/21688370.2021.1967080
22
ShitaraKLordickFBangYJEnzingerPIlsonDShahMAet al. Zolbetuximab plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT): a multicentre, randomised, double-blind, phase 3 trial. Lancet (London England). (2023) 401:1655–68. doi: 10.1016/S0140-6736(23)00620-7
23
WangFHZhangXTTangLWuQCaiMYLiYFet al. The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023. Cancer Commun (London England). (2024) 44:127–72. doi: 10.1002/cac2.12516
24
TüreciÖMitnacht-KrausRWöllSYamadaTSahinU. Characterization of zolbetuximab in pancreatic cancer models. Oncoimmunology. (2019) 8:e1523096. doi: 10.1080/2162402X.2018.1523096
25
MaYConfortiRAymericLLocherCKeppOKroemerGet al. How to improve the immunogenicity of chemotherapy and radiotherapy. Cancer metastasis Rev. (2011) 30:71–82. doi: 10.1007/s10555-011-9283-2
26
SprootenJLaureanoRSVanmeerbeekIGovaertsJNaulaertsSBorrasDMet al. Trial watch: chemotherapy-induced immunogenic cell death in oncology. Oncoimmunology. (2023) 12:2219591. doi: 10.1080/2162402X.2023.2219591
27
SaitoAOhzawaHKawashimaRMatsumotoSKurashinaKSaitoSet al. Expression of Claudin18.2 in metastatic lesions in peritoneum of gastric cancer. J gastrointestinal Oncol. (2025) 16:67–76. doi: 10.21037/jgo-24-743
Summary
Keywords
gastric cancer, peritoneal metastasis, HIPEC, Claudin18.2, targeted therapy
Citation
Li W, Huang X, Han X, Zhang J, Ma B, Yin Z, Wang Y, Gao L, Shi J and Chen H (2025) Sequential HIPEC, Claudin18.2-targeted therapy, and CapeOx chemotherapy leading to resolution of peritoneal metastases and curative resection in gastric cancer: a case report and literature review. Front. Immunol. 16:1641424. doi: 10.3389/fimmu.2025.1641424
Received
05 June 2025
Accepted
30 October 2025
Published
18 November 2025
Volume
16 - 2025
Edited by
Neal Bhutiani, University of Louisville, United States
Reviewed by
Denis Kutilin, National Medical Research Center of Oncology, Russia
Santhosh Shanthi Bhupathi, West Virginia University, United States
Updates
Copyright
© 2025 Li, Huang, Han, Zhang, Ma, Yin, Wang, Gao, Shi and Chen.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Hao Chen, ery_chenh@lzu.edu.cn
† These authors have contributed equally to this work
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.