EDITORIAL article

Front. Immunol.

Sec. Inflammation

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1644324

This article is part of the Research TopicCommunity Series in Pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease: Volume IIView all 10 articles

Editorial：Pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease Volume II

Provisionally accepted
Ke HanKe Han1,2Ping-Ting ZhouPing-Ting Zhou1Zi-Hui XieZi-Hui Xie1Yi-Fan CaiYi-Fan Cai3Ziyue FuZiyue Fu1Bingyu LiangBingyu Liang1Fen-Fen LiFen-Fen Li1Bu-Sheng TongBu-Sheng Tong1*Yuchen LiuYuchen Liu1,2*Hai-Feng PanHai-Feng Pan2*
  • 1Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China
  • 2Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
  • 3The First School of Clinical Medicine, Anhui Medical University, Hefei, China

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The immune system maintains homeostasis through a sophisticated, multi-layered regulatory framework. Pattern recognition receptors enable the discrimination between self and non-self, while dynamic interactions among T cell subsets and cytokines establish precise immunomodulatory networks. 1,2 When disrupted, this protective system becomes pathogenic. Recognition errors trigger excessive signaling; pathogens exploit antigenic variation for immune escape. 3,4 Inflammatory dysregulation perpetuates chronic systemic pathology through sustained cytokine release and regulatory defects, creating destructive feedback loops. 5,6 Modern immunology is currently exploring immune reconstitution for clinical treatment. 7 Emerging therapeutic targets now allow precise modulation of T cell function within acidic microenvironments 8 , while single-cell multi-omics technologies are enabling patient-specific immune profiling for personalized interventions, 9

Keywords: Immune homeostasis, autoimmune disease, molecular mechanism, therapy, Immune imbalance

Received: 10 Jun 2025; Accepted: 10 Jun 2025.

Copyright: © 2025 Han, Zhou, Xie, Cai, Fu, Liang, Li, Tong, Liu and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Bu-Sheng Tong, Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Yuchen Liu, Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Hai-Feng Pan, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material