REVIEW article
Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1645503
Biochemical Markers and Emerging Therapies for Intestinal Manifestation of Graft-versus-Host Disease
Provisionally accepted
- Medical University of Warsaw, Warsaw, Poland
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Graft-versus-host disease (GVHD) remains a potentially fatal complication of allogeneic hematopoietic stem cell transplantation (alloHCT). Gastrointestinal involvement, whether in acute or chronic GVHD, is associated with a poorer prognosis and poses significant diagnostic and therapeutic challenges. Numerous studies have attempted to identify markers that could facilitate the diagnosis and predict the course of GVHD. Among them, REG3α and ST2 currently show the greatest promise, however, comprehensive validation remains lacking. Although several new drugs have been approved for GVHD treatment in recent years and some modifications to GVHD prophylaxis have been adopted into clinical practice, further research are needed to validate biomarkers and explore new therapeutic targets, particularly in gastrointestinal GVHD. The review aims to summarize current research on GVHD biomarkers and emerging treatment targets, with a particular focus on gastrointestinal tract disease.
Keywords: graft versus host disease, Allogeneic hematopoietic cell transplantation, Gastrointestinal Tract, biomarkers, GvHD treatment
Received: 11 Jun 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Wiejak, Przybyłkowski and Tomaszewska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Adam Marcin Przybyłkowski, Medical University of Warsaw, Warsaw, Poland
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