EDITORIAL article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1646413
This article is part of the Research TopicMitochondrial damage interacts with the immune system and tumor microenvironmentView all 7 articles
Editorial:Mitochondrial damage interacts with the immune system and tumor microenvironment
Provisionally accepted
- Southern Medical University, Guangzhou, China
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Despite the clinical success of immunotherapy in certain cancers, patient sensitivity and resistance remain persistent challenges. As the primary energy powerhouses of eukaryotic cells, mitochondria exhibit dysfunction and metabolic perturbations that alter endogenous molecular expression (1,2). Mitochondria also extensively participate in emerging cell death processes such as ferroptosis and cuproptosis, consequently reshaping the infiltration and functional state of tumor immune cells. Exploring mitochondria-associated targets and their crosstalk with cell death pathways represents a potential approach to overcome immunotherapy resistance.
Keywords: Cancer, Mitochondrial damage, immune response, Tumor Microenvironment, Cell Death, immune therapy
Received: 13 Jun 2025; Accepted: 18 Jun 2025.
Copyright: © 2025 Guo, Fang, Lin, Yuan and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weihong Guo, Southern Medical University, Guangzhou, China
Haihong Fang, Southern Medical University, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.