REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1646527
This article is part of the Research TopicNew Insights into Inflammation Driven Autoimmune Skin Disorders: Trends and ChallengesView all 14 articles
NETs: A new target for autoimmune disease
Provisionally accepted
- 1Anhui University of Chinese Medicine, Hefei, China
- 2University of Science and Technology of China Faculty of Life Sciences and Medicine, Hefei, China
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Neutrophil extracellular traps (NETs) are reticular fiber structures released by neutrophils in response to various stimuli. Although NETs have antibacterial defense functions, their excessive formation has been proven to accelerate the progression of autoimmune diseases. Increasing studies have shown that NETs play an important role in the pathogenesis of autoimmune diseases. The pathogenesis of recent advances in autoimmune disease research, with a focus on the role of NETs in the etiology and pathogenesis of these disorders, and summarizes the current treatment strategies targeting NETs, aiming to provide new directions for the treatment of autoimmune diseases.
Keywords: Neutrophil, neutrophil extracellular traps, autoimmune disease, Mechanism, targeted therapy
Received: 13 Jun 2025; Accepted: 10 Oct 2025.
Copyright: © 2025 Jia, Tang, Qin and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyi Jia, jiaxy@ahtcm.edu.cn
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