CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1646850
Retinal Vasculitis and Optic Neuritis in SLE
Provisionally accepted
- 1Department of Rheumatology, Weifang People’s Hospital, Weifang, China
- 2Department of Ophthalmology, Weifang People’s Hospital, Weifang, China
- 3Department of Cardiology, Yidu Central Hospital of Weifang, Weifang, China
- 4Department of Radiology, Weifang People’s Hospital, Weifang, Weifang, China
- 5Beijing University of Chinese Medicine, Beijing, China
- 6Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China
- 7Department of Rheumatology and Immunology, International Hospital, Peking University, Beijing, China
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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect the ocular system, with retinal vasculitis and optic neuritis being rare but serious manifestations.We present a case of a 26-year-old female with newly diagnosed SLE who developed both retinal vasculitis and optic neuritis, leading to progressive visual impairment. She was Retinal Vasculitis and Optic Neuritis in SLE 3 successfully treated with methylprednisolone and rituximab, achieving significant visual recovery. A review of existing literature highlights the diagnostic challenges, pathophysiology, and optimal treatment strategies for such cases. Our findings emphasize the importance of early recognition and aggressive immunosuppressive therapy in improving patient outcomes.
Keywords: systemic lupus erythematosus, Retinal Vasculitis, Optic Neuritis, Autoimmune ocular disease, immunosuppressive therapy
Received: 14 Jun 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Jin, Liu, Wang, Fang, Nie, Li, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chen Li, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China
Ming Li, Department of Rheumatology, Weifang People’s Hospital, Weifang, China
Sheng-Guang Li, Department of Rheumatology and Immunology, International Hospital, Peking University, Beijing, China
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