ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1647807
This article is part of the Research TopicRegulation of Gene Expression by RNA Processing Steps in CancersView all articles
Exploring the Carcinogenic Potential of Bisphenol A in Lung Adenocarcinoma: Molecular Mechanisms, Key Gene Insights, and Immune Microenvironment Impacts
Provisionally accepted
- 1Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Guangzhou, China
- 2Nanchang University, Nanchang, China
- 3Central South University, Changsha, China
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This study investigates how Bisphenol A (BPA), an endocrine-disrupting chemical, affects lung adenocarcinoma (LUAD) development by examining key genes and their impact on tumor progression and the immune microenvironment. Using network toxicology, molecular docking, and clinical data analysis, we identified 218 common genes between BPA targets and LUAD biomarkers, including BUB1, BUB1B, CCNA2, CDK1, and UBE2C. These genes are associated with LUAD progression, poor survival outcomes, and increased immune cell infiltration. Molecular docking showed strong binding between BPA and these proteins, potentially disrupting their normal function. The study underscores BPA's risks in LUAD, suggesting these genes could serve as biomarkers and therapeutic targets, warranting further research for public health strategies.
Keywords: bisphenol A, Lung Adenocarcinoma, Oncogenic genes, Tumor Microenvironment, molecular docking
Received: 16 Jun 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Chen, Jiang, Yang, Cai, Jiang and Ouyang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenhao Ouyang, auyeung3@alumni.sysu.edu.cn
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