REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1648757
The crosstalk of Caveolin-1 and autophagy in different diseases
Provisionally accepted
- 1The Second Hospital of Dalian Medical University, Dalian, China
- 2Wuxi People's Hospital, Wuxi, China
- 3ICU, Diamond Bay District, The Second Affiliated Hospital of Dalian Medical University, Dalian, China
- 4Air Force Medical Center, Beijing, China
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Caveolin-1 (Cav-1) is an important structural protein that constitutes the caveolae on the cell membrane. Cav-1 is expressed in various cells, especially in white adipocytes and endothelial cells. Cav-1 plays an important physiological role in regulating substance transport, signal transduction, and multiple metabolic pathways in the body. Autophagy degrades damaged organelles within cells and recycles them, thus playing an important role in maintaining homeostasis of the internal environment. Previous studies have found that Cav-1 is involved in the occurrence and development of multiple systemic diseases by regulating autophagy. In addition, autophagy can also affect the expression level of Cav-1 by degrading it. Therefore, there is a close regulatory relationship between Cav-1 and autophagy. Based on recent research progress, this article provides a detailed overview of the importance of the crosstalk between Cav-1 and autophagy in various systemic diseases such as cardiovascular, respiratory, and digestive systems. It aims to provide a more comprehensive understanding of the interaction between Cav-1 and autophagy, in order to promote further research and achieve clinical applications as soon as possible.
Keywords: caveolin-1, Autophagy, Disease mechanisms, Molecular regulation, signalingpathways
Received: 17 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Yang, Ma, Yang, Wei, Wang, Jiang, Liu and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hui Liu, The Second Hospital of Dalian Medical University, Dalian, China
Mei Han, The Second Hospital of Dalian Medical University, Dalian, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.