REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1649597
New insights into mesenchymal stem cells in inflammatory subtypes of asthma
Provisionally accepted
- Second Affiliated Hospital of Jilin University, Changchun, China
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Asthma is a heterogeneous disease characterized by chronic airway inflammation, heightened reactivity, and structural remodeling. The responses of different phenotypes to traditional corticosteroid therapy vary significantly, with steroid resistance in low T-helper type 2 asthma remaining an urgent clinical challenge. In recent years, mesenchymal stem cells (MSCs) and their exosomes-mesenchymal stem cell-derived extracellular vesicles (MSC-EVs)-have emerged as promising therapeutic agents due to their potent immunomodulatory properties. In this review, we systematically explain how MSCs and MSC-EVs inhibit airway inflammation in asthma through multitarget immunoregulation, highlight their therapeutic potential in steroid-resistant asthma, and outline the challenges and optimization strategies involved in clinical translation, thereby providing a theoretical foundation for the development of novel therapies.
Keywords: Asthma, Inflammation, Mesenchymal Stem Cells, Exosomes, Immunomodulation, cell-based therapy
Received: 18 Jun 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Hou, Hao, Zhang, Li and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peng Gao, Second Affiliated Hospital of Jilin University, Changchun, China
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