SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1653429
Efficacy and safety of camrelizumab plus apatinib for solid tumors: a meta-analysis
Provisionally accepted
- Taihe Hospital, Hubei University of Medicine, Shiyan, China
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Objective: This study used meta-analysis to explore the efficacy and safety of camrelizumab plus apatinib in the treatment of solid tumors. Methods: PubMed, Embase, web of science, and Cochrane library databases were searched for this study, and the searches were conducted from database creation to August 13, 2025. The minors (methodological index for nonrandomized studies) score was used to evaluate the quality of the included studies, and the meta-package in R4.3.3 was used to analyze the data. Result: The analysis of 35 publications involving 2224 patients revealed various adverse events and survival outcomes. Adverse events of any grade included anemia (ES=0.446), diarrhea (ES=0.217), hypertension (ES=0.478), proteinuria (ES=0.402), and fatigue (ES=0.328). For grade1-2, adverse events, the effect sizes ranged from 0.146to 0.306. For grade ≥3 adverse events, the effect sizes ranged from 0.004 to 0.065. The Objective Response Rate (ORR) was 40.0%, with a Disease Control Rate (DCR) of 78.0%. Overall Survival (OS) rates at 6, 12, and 24 months were 79.0%, 46.5%, and 16.0%, respectively. Progression-Free Survival (PFS) rates at the same intervals were 48.4%, 19.8%, and 6.7%. Conclusion: According to the results of this meta-analysis, although the camrelizumab plus apatinib treatment regimen demonstrated certain efficacy in the short term, due to the significant limitations of this study, more high-quality, multicenter, large-sample randomized controlled studies are needed in the future to corroborate our conclusions.
Keywords: camrelizumab, Apatinib, solid tumors, Meta-analysis, efficacy
Received: 25 Jun 2025; Accepted: 20 Aug 2025.
Copyright: © 2025 Yu, Song, li, Chen, Zhou and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuan Zhou, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Fei Jiang, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.