REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
This article is part of the Research TopicMetabolism in the Tumour Microenvironment: Implications for Pathogenesis and TherapeuticsView all 9 articles
Metabolic reprogramming and immune regulation in acute myeloid leukemia
Provisionally accepted
Xiaogang Hao*
Chenyang Fan
Lixiang Yan
JIANATI ReailaYifei GuoXinli Zhou
Gengda ZhuYucheng ZhangChengyulong ZhengYing Zhang
Zhexin Shi*- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The most prevalent kind of acute leukemia in adults is acute myeloid leukemia (AML). While 24 some individuals have had better effectiveness due to advancements in targeted medications, 25 2 recurrence after remission and inadequate treatment specificity continue to be significant 26 therapeutic problems. By controlling essential metabolic pathways and metabolites, metabolic 27 reprogramming, a crucial strategy for cellular adaptability to energy needs, modifies cellular 28 metabolic rhythms. In addition to being involved in immune cell proliferation, differentiation, and 29 effector function, this pathway is also essential for leukemogenesis and survival signaling in AML. 30 By altering the expression of immune molecules, the release of certain metabolites (such as lactate, 31 ROS, glutamine, etc.) has a significant impact on the immune response to tumors. It is noteworthy 32 that the metabolic interactions between immune cells and AML cells form a distinct pattern of 33 energy competition in the tumor microenvironment. This study examined the new approach of 34 targeting metabolic pathways to improve immunotherapy, systematically clarified the regulatory 35 mechanism of metabolic reprogramming between AML cells and immune cells to counteract 36 tumor immunity, and concentrated on the synergistic effect of current therapies and metabolic 37 interventions. These findings offered a fresh perspective on how to fully realize the potential of 38 metabolic therapy for AML.
Keywords: AML, metabolic reprogramming, Immune Regulation, review, Metabolism
Received: 27 Jun 2025; Accepted: 25 Nov 2025.
Copyright: © 2025 Hao, Fan, Yan, Reaila, Guo, Zhou, Zhu, Zhang, Zheng, Zhang and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaogang Hao
Zhexin Shi
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.