MINI REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1655573
Hydroxychloroquine's Diverse Targets: A New Frontier in Precision Medicine
Provisionally accepted
- Changzhi Medical College, Changzhi, China
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Despite extensive research, comprehensive reviews focusing on HCQ's direct targets and mechanisms are limited. This review seeks to systematically elucidate HCQ's interactions with nucleic acids, proteins, and lipids, thereby uncovering the fundamental mechanisms responsible for its therapeutic benefits and adverse effects. Such insights will aid in developing personalized treatment strategies based on biomarkers (e.g., circulating tumor DNA levels, lysosomal enzyme activity), thereby transforming HCQ's "double-edged sword" effect into an advantage for precision medicine.
Keywords: hydroxychloroquine;, Autophagy, Mitochondrial damage, Nucleic acid targeting, Membrane structure remodeling, clinical application
Received: 28 Jun 2025; Accepted: 16 Sep 2025.
Copyright: © 2025 Wang, du, li, li and liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pu Wang, 372746529@qq.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.