REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1657194
This article is part of the Research TopicMetabolic Implications in Sepsis and Inflammation-related Critical IllnessesView all articles
Role of novel protein acylation modifications in sepsis
Provisionally accepted
- 1Northern Jiangsu People's Hospital, Yangzhou, China
- 2Affiliated Hospital of Yangzhou University, Yangzhou, China
- 3Binhai County People's Hospital, Yancheng, China
- 4Xuzhou Medical University, Xuzhou, China
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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, exhibiting high global morbidity and mortality. Accumulating evidence indicates that post-translational modifications (PTMs), as pivotal epigenetic mechanisms, play a crucial role in regulating diverse biological processes. The significance of PTMs in sepsis is increasingly recognized, as they may influence disease progression by modulating protein stability, activity, and localization. In recent years, advances in mass spectrometry have elucidated a series of novel PTMs, including succinylation (Ksucc), S-palmitoylation, lactylation (Kla), crotonylation (Kcr), 2-hydroxyisobutyrylation (Khib), β-hydroxybutyrylation (Kbhb), and malonylation (Kmal). This review presents the first comprehensive analysis of the characteristics, functions, and implications of these seven lysine acylation modifications in the pathogenesis and progression of sepsis, aiming to provide valuable insights for diagnosis and therapeutic intervention.
Keywords: Sepsis, epigenetics, Acylation, Organ dysfunction, Inflammation
Received: 01 Jul 2025; Accepted: 18 Sep 2025.
Copyright: © 2025 Wang, He, Song, Jiang, Xu, Zheng and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ruiqiang Zheng, zhengruiqiang2021@163.com
Jiangquan Yu, yujiangquan2021@163.com
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