REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1659342
Therapeutic Roles and Molecular Mechanisms of Cuscutae Semen in Reproductive Diseases
Provisionally accepted
- 1School of Pharmacy, Hangzhou Medical College, Hangzhou, China
- 2School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College,, Hangzhou, China
- 3Department of Traditional Chinese Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China
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Cuscutae Semen (CS), one of the herbs in traditional Chinese medicine, has been recorded for a long time and contains various bioactive compounds, including flavonoids, phenolic acids, lignans, and polysaccharides. These compounds contribute to the medicinal effects on reproductive health. This review examines the therapeutic applications of CS in male and female reproductive diseases, its toxicity, and potential herb-drug interactions. This study focused on the medicinal roles and possible molecular mechanisms of CS in the treatment of reproductive diseases, such as male and female infertility, premature ovarian insufficiency, recurrent spontaneous abortion, and polycystic ovary syndrome. This review examines the mechanisms by which CS regulates the hypothalamic-pituitary-gonadal axis, hormone levels, and key molecules and signaling pathways crucial for reproductive health. By elucidating the potential mechanisms of CS action in reproductive endocrine disorders, this study aimed to provide a scientific basis and evidence for its clinical application in these conditions. These findings provide insights into the molecular mechanisms by which CS has significant potential for treating a range of reproductive disorders.
Keywords: Cuscutae semen, herb, Reproductive disease, Infertility, PREMATURE OVARIAN INSUFFICIENCY, recurrentspontaneous abortion, Polycystic Ovary Syndrome, Hypothalamus-pituitary-gonadal axis
Received: 09 Jul 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Li, Zheng, Hao, Kong and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kun Li, School of Pharmacy, Hangzhou Medical College, Hangzhou, China
Qianru Zhou, Department of Traditional Chinese Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.