REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1659614
This article is part of the Research TopicCommunity Series in Immune Cell Therapy Approaches Targeting Tumor Microenvironment: Volume IIView all articles
Notch Signalling in T cells: Bridging Tumour Immunity and Intratumoral Cellular Crosstalk
Provisionally accepted
Jasmine Sultana1
Pritha Roy Choudhury1
Saurav Bera2
Mohona Chakravarti3
Aishwarya Guha1Prodipto Das1Juhina Das1Gayatri S Iyer4
Anirban Sarkar1
Sukanya Dhar1
Nilanjan Ganguly1
Rathindranath Baral1
Anamika Bose5
Dr. Saptak Banerjee1*- 1Chittaranjan National Cancer Institute (CNCI), Kolkata, India
- 2Chittaranjan National Cancer Institute, Kolkata, India
- 3National Cancer Institute Surgery Branch, Bethesda, United States
- 4KIIT School of Biotechnology, Bhubaneswar, India
- 5National Institute of Pharmaceutical Education and Research, Sahibzada Ajit Singh Nagar, India
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Background: Notch receptor-ligand interaction is ubiquitous for coordinating cellular differentiation and determining cell fate for the development of various tissues and organs. Aberrant mutations in the Notch cascade results in various patho-physiological disorders inclusive of cancer. Diverse aspects of carcinogenesis regulated by Notch includes shaping of antitumour T cell immunity through APC-T cell interaction and effector function. Chief content: Notch depends on juxtacrine and paracrine signalling for influencing inter-cellular communications in tumour micro-environment. Several preclinical and clinical studies reveal Notch as a bi-effector molecule which has differential effect depending on the immune contexture of the tumour-micro-environment. The Notch cascade serves as an effective therapeutic target in preventing off target cell death and promoting tumour specific T cell priming. Conclusion: This review revolves around Notch crosstalk with respect to the interaction between T cell populations and other intratumoral cellular components including professional Antigen Presenting Cells like Dendritic Cells, Macrophages, B cells, immunosuppressive Myeloid Derived Suppressor Cells and Cancer Stem Cells. It also summarizes the impact of targeting Notch signalling within intratumoral T cells in combination with traditional onco-therapies.
Keywords: Notch, T cells, Macrophages, Dendritic Cells, myeloid derived suppressor cells, B cells, Targeted-Therapy
Received: 04 Jul 2025; Accepted: 12 Sep 2025.
Copyright: © 2025 Sultana, Choudhury, Bera, Chakravarti, Guha, Das, Das, Iyer, Sarkar, Dhar, Ganguly, Baral, Bose and Banerjee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Saptak Banerjee, Chittaranjan National Cancer Institute (CNCI), Kolkata, India
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