CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1659720
Cerebrospinal Fluid Eosinophilia in Adult Autoimmune GFAP Astrocytopathy: A Case Report
Provisionally accepted
- General Hospital of Ningxia Medical University, Yinchuan, China
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A 30-year-old Chinese male diagnosed with autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy presented with cerebrospinal fluid (CSF) eosinophilia. Magnetic resonance imaging (MRI) revealed no significant abnormalities; however, CSF analysis demonstrated positive GFAP-immunoglobulin G (IgG) antibodies. Notably, the CSF showed marked eosinophilia, which declined following methylprednisolone therapy, accompanied by clinical improvement. The percentage of eosinophils in the CSF of this patient exceeded previously documented levels in cases of autoimmune GFAP astrocytopathy. These findings suggest a potential relationship between eosinophil infiltration and the pathogenesis of autoimmune GFAP astrocytopathy, indicating that eosinophils may contribute to disease progression.
Keywords: Glial Fibrillary Acidic Protein (GFAP), Cerebrospinal Fluid, cytologic evaluation, eosinophil, case report
Received: 04 Jul 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Yuting, Chunmei and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hou Yuting, houyt317@163.com
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