SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1659848
This article is part of the Research TopicImmune Responses in Neurodegeneration: Opportunities for Targeted InterventionsView all articles
Research on Parkinson's disease immunotherapy: A bibliometric analysis via multiple databases
Provisionally accepted
- 1Chengdu Eighth People’s Hospital, Chengdu, China
- 2West China Hospital of Sichuan University, Chengdu, China
- 3The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 4Chengdu Medical College The First Affiliated Hospital, Chengdu, China
- 5Università di Bologna, Campus di Cesena, Cesena, Italy
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Background Parkinson's disease (PD) is a neurodegenerative disorder involving degeneration of dopaminergic neurons in the substantia nigra, abnormal aggregation of α-synuclein, and neuroinflammatory response. Although research on PD immunotherapy is advancing rapidly, bibliometric analysis in this field remains underdeveloped. Methods Literature related to "Parkinson's disease" and "immunotherapy" from the Web of Science Core Collection and Scopus was used for data merging and bibliometric analysis via Bibliometrix. The characteristics of the relevant clinical trials in this field retrieved from the PubMed database were summarized, and the study protocols were traced back through the trials registry website. Results After merging the two databases, a total of 890 documents from 488 sources were covered. A total of 3,804 researchers from 1,483 institutions in 63 countries published research in this field. Authors, institutions, and countries/regions were classified into 5, 12, and 13 clusters, respectively. Keywords such as "Parkinson's disease", "immunotherapy", and "alpha-synuclein" were frequently used. The maps of keyword co-occurrence and clusters revealed the generation of two clusters. A total of 8 clinical trials were searched and included. These trials focused on active immunotherapy and targeted antibodies, involving both healthy volunteers and patients with PD. Conclusions The field of PD immunotherapy has vigorous development potential. The current research focus in this field is concentrated on analyzing pathological mechanisms and innovating treatment strategies. Precise immunological intervention techniques are frontiers in this field. In the future, large-scale randomized controlled trials should be conducted to enhance the clinical translation efficiency of immunotherapy.
Keywords: Parkinson's disease, Immunotherapy, Bibliometrics, hotspots, Frontiers
Received: 04 Jul 2025; Accepted: 23 Sep 2025.
Copyright: © 2025 Fei, Wang, Song, Cao, Gao and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yaqian Gao, 673509366@qq.com
Yue Hu, huyue@swmu.edu.cn
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