ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1662830
This article is part of the Research TopicCommunity Series in Tumor Microenvironment and Metabolic Reprogramming in Cancer: Volume IIView all 9 articles
IMPLICATION OF LAMP PROTEINS AND AUTOPHAGY MARKERS IN COLORECTAL CANCER AGGRESSIVENESS
Provisionally accepted
Tsvetomira Ivanova1,2*
Dorian Dikov3
Diana Molander1,2
Angel Dzhambov4
Yordan Sbirkov1,2Nikolay Mehterov1,2Nikolay Belev5
Boyko Atanasov6Maria Kazakova1,2Victoria Sarafian1,2*- 1Department of Medical Biology, Medical University of Plovdiv, Plovdiv, Bulgaria
- 2Research Institute at Medical University of Plovdiv, Plovdiv, Bulgaria
- 3Department of Pathology, Grand Hospital del`Este Francilen, Jossigny, France
- 4Environmental Health Division, Research Institute at Medical University of Plovdiv, Plovdiv, Bulgaria
- 5University Hospital ¨EUROHOSPITAL¨, Plovdiv, Bulgaria
- 6University Hospital ¨UNIHOSPITAL¨, Plovdiv, Bulgaria
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ABSTRACT: Lysosome-associated membrane proteins (LAMPs) play a critical role in various cellular processes, including phagocytosis, lipid transport, neoangiogenesis, and tissue remodeling. Recent discussions have focused on their involvement in autophagy related to tumor progression. Emerging studies have underscored the connection between tumorigenesis and autophagy, highlighting that dysregulation of this process is associated with the resistance of tumor cells to conventional chemotherapy across numerous malignancies, including colorectal cancer (CRC). Currently, there is a notable absence of reliable prognostic biomarkers for effectively stratifying and predicting treatment responses in CRC patients (n=79). Our study examines the expression of LAMP1 and LAMP2 proteins and genes alongside key autophagy markers such as BECLIN1 and LC3B, investigating their relationships with CRC invasiveness. We present original data illustrating the association of LAMP molecules with standard autophagy markers and tumor budding. Our findings provide novel insights into the significance of these markers in CRC invasiveness, their relationship with survival rates, and their potential role as prognostic biomarkers.
Keywords: LAMP1, LAMP2, Beclin1, LC3B, tumor budding, liquid biopcy
Received: 09 Jul 2025; Accepted: 10 Sep 2025.
Copyright: © 2025 Ivanova, Dikov, Molander, Dzhambov, Sbirkov, Mehterov, Belev, Atanasov, Kazakova and Sarafian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tsvetomira Ivanova, tzvetence@gmail.com
Victoria Sarafian, victoria.sarafian@mu-plovdiv.bg
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