REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1663423
This article is part of the Research TopicNeural influences on tumor immunity: Exploring neuroimmunology in cancerView all 17 articles
The inspiration of methyltransferase in RNA methylation modification for targeted therapy of malignant tumors
Provisionally accepted
Xinru Chen1
Xinyu Liu1
Jiaqi Xu1
Xingyu Zhu1Bingyao Liu1Xinhao Yang1Ge Cong1
Xiaoyan Lin1*
Wei Chong1*
Hao Chen2*- 1Shandong Provincial Hospital, Jinan, China
- 2Qilu Hospital of Shandong University, Jinan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Abstract: RNA methylation modification has always been a research hotspot. RNA methylation modification can regulate processes such as transcription, translation, splicing, stability, and degradation of RNA, in which effector proteins play an important role, including 'writers', 'erasers', and 'readers'. There are various types of proteins involved in cancer progression, and in recent years, research on their mechanisms of action has been increasing, providing new ideas for targeted cancer therapy. By regulating the expression of related genes and affecting signaling pathways, protein writing plays a role in promoting or inhibiting cancer in the proliferation, invasion, migration, and metastasis of different tumors, providing direction for the treatment of malignant tumors. This article reviews the mechanisms of common RNA methylation modified writers and their prospects in targeted cancer therapy.
Keywords: RNA methylation modification, writer, Malignant tumor, mechanism of action, targeted therapy
Received: 10 Jul 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Chen, Liu, Xu, Zhu, Liu, Yang, Cong, Lin, Chong and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoyan Lin, linxiaoyanyan@163.com
Wei Chong, chongwei@sdfmu.edu.cn
Hao Chen, qiluchenhao@email.sdu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.