REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1666261
This article is part of the Research TopicThe Role of Neutrophil Extra Cellular Traps (NETs) Formation in Tumor Microenvironment- from Basic Research to Clinical ApplicationsView all 5 articles
NETs -as predictors and targets of supportive therapy for cancer treatment
Provisionally accepted
Maria-Laura Morawiec1*
Robert Kubina1,2
Ewa Jabłońska3
Wioletta Ratajczak-Wrona3
Sebastian Stępień1Maciej Gołębski1
Aleksandra Mielczarek-Palacz1- 1Medical University of Silesia, Katowice, Poland
- 2Silesia LabMed: Centre for Research and Implementation, Medical University of Silesia in Katowice, Katowice, Poland
- 3Uniwersytet Medyczny w Bialymstoku, Bialystok, Poland
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NETs are network-like structures consisting mainly of DNA and various proteins released by neutrophils physiologically in response to pathogens. Moreover, according to recent reports, NETs also play an important role in carcinogenesis. They are involved in all stages of carcinogenesis, assist in the process of metastasis, and their presence has been linked to higher mortality and poorer prognosis in numerous cancer types. This review focuses on anti-cancer treatments related to disintegration of existing NETs, inhibition of their formation and regulation of their formation. Cases in which the presence of NETs was associated with anticancer activity and the association of NETs with complications co-occurring with cancer or related to cancer treatment was presented. This paper also presents mechanisms of NETs inhibition, predicting the efficacy or resistance of anti-cancer therapy associated with NETs.
Keywords: NETs, therapy, Cancer, chemoresistance, DNase 1
Received: 15 Jul 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Morawiec, Kubina, Jabłońska, Ratajczak-Wrona, Stępień, Gołębski and Mielczarek-Palacz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Maria-Laura Morawiec, Medical University of Silesia, Katowice, Poland
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