SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Primary Immunodeficiencies
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1666600
Allergic Manifestations in Inborn Errors of Immunity: A Systematic Scoping Review
Provisionally accepted- 1Division of Immunology and Children’s Research Center, University Children's Hospital Zurich, Zurich, Switzerland
- 2Division of Allergy and Immunology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, United States
- 3Division of Allergy and Children’s Research Center, University Children's Hospital Zurich, Zurich, Switzerland
- 4Universitat Zurich Medizinische Fakultat, Zürich, Switzerland
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BACKGROUND: Allergic diseases resulting from aberrant immune function are frequently observed in patients with inborn errors of immunity (IEI). However, the underlying monogenic disorders may not be initially diagnosed, which leads to delays in appropriate diagnosis and treatment. Although recent studies have highlighted the link between IEI and allergic conditions, earlier case series might not have been fully exploited. OBJECTIVE: To compile a comprehensive database of IEI cases in the literature, analyze the prevalence and characteristics of allergic diseases, and assess the latter's association with other forms of immune dysregulation. METHOD: A systematic scoping review of the literature. RESULTS: A total of 738 articles (reporting on 3050 individual patients) were included. 226 (7.4%) of the patients were described as suffering from an allergy. Monogenetic diseases associated with a marked prevalence of allergy were found in various IEI subgroups. Food allergy was most frequently reported (n=172, 76.1%), followed by allergic rhinitis (n=56, 24.8%). The presence of allergy in patients with IEI was generally associated with the absence of other forms of immune dysregulation, although there were notable exceptions. The overall prevalence of atopic conditions (food allergy, allergic rhinitis, asthma, and eczema) in the dataset was 26.9% (n=821). CONCLUSION: This systematic scoping review emphasized the relevance of allergic diseases as a manifestation of immune dysregulation in IEI. Our findings might raise awareness of allergy in IEI among clinicians and researchers and constitute a valuable resource for better diagnosis and management of these conditions.
Keywords: inborn errors of immunity, Primary immunodeficiency, allergy, Atopy, Immune dysregulation, Systematic scoping review
Received: 15 Jul 2025; Accepted: 19 Sep 2025.
Copyright: © 2025 Marbet, Gujer, Münger, Killian, Mauracher, Soomann, Trück and Pachlopnik Schmid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jana Pachlopnik Schmid, jana.pachlopnik@kispi.uzh.ch
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