MINI REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1673383
This article is part of the Research TopicTumor Microenvironment: Inflammation and Immune Signal Transduction at Single-Cell ResolutionView all 17 articles
Exercise Induced Immune Regulation and Drug Efficacy in Rhinitis and Nasopharyngeal Carcinoma with Implications for Tumor Microenvironment and Single Cell Immune Signal Transduction
Provisionally accepted
Guanwen He1,2,3*Weijing Bao1,2Jiansheng Yang4Xiuqin Guo1,2Wenxian Lu1,2Xiuhui Ji5Shang Gao1,2,6*
Rifu Wei1,2*
Yisheng Chen1,2,4*- 1Ningde Municipal Hospital of Ningde Normal University, Ningde, China
- 2Ningde Clinical Medical College of Fujian Medical University, Ningde, China
- 3Pingnan General Hospital of Ningde Hospital Medical Group, Ningde, China
- 4Ningde Normal University, Ningde, China
- 5Nanjing Medical University, Nanjing, China
- 6Shanghai General Hospital, Shanghai, China
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Emerging evidence reveals that exercise modulates immune signaling to enhance the efficacy of immunotherapy in diseases like allergic rhinitis (AR) and nasopharyngeal carcinoma (NPC). By influencing immune cell trafficking, reprogramming inflammatory pathways within the tumor microenvironment (TME), and altering drug pharmacokinetics, exercise improves immune responses and therapeutic outcomes. Exercise enhances immune cell activation and infiltration into tumors, modulates checkpoint and cytokine signaling cascades, and mitigates treatment-related side effects, thereby improving patient compliance. Recent advancements in single-cell technologies, such as single-cell RNA sequencing and spatial omics, provide unprecedented insights into immune cell heterogeneity and signal transduction dynamics in the TME, uncovering new targets for exercise-modulated therapies. This review explores the synergistic effects of combining exercise with immune-based therapies, particularly in cancer treatment, highlighting the role of exercise in reshaping TME inflammation, overcoming immune evasion, and enhancing immune-mediated drug bioavailability. Personalized exercise regimens, tailored to individual patient profiles, are critical for optimizing therapeutic responses. Integrating exercise with immunotherapy, guided by single-cell and systems-level analyses, may provide a transformative approach for improving the clinical outcomes of AR and NPC patients, paving the way for more effective, individualized cancer treatments.
Keywords: Exercise, Tumor Microenvironment, immune signal transduction, single cell, Immunotherapy, Inflammation, nasopharyngeal carcinoma, allergic rhinitis
Received: 25 Jul 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 He, Bao, Yang, Guo, Lu, Ji, Gao, Wei and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guanwen He, gjln5802@21cn.com
Shang Gao, gmjj4889@21cn.com
Rifu Wei, weesebriarzi@hotmail.com
Yisheng Chen, yschen21@m.fudan.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.