EDITORIAL article
Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1673414
This article is part of the Research TopicImmunity in Aging and Age-related Diseases and DysfunctionsView all 7 articles
Editorial: Immunity in Aging and Age-related Diseases and 1 Dysfunctions 2
Provisionally accepted
- 1University of Palermo, Palermo, Italy
- 2Duke University Hospital, Durham, United States
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Aging of the immune system, referred to as immunosenescence, is characterized by age-related 16 alterations in both the adaptive and innate immune responses [1; 2]. These age-associated immune 17 changes drive the accumulation of senescent cells and the development of the senescence-associated 18 secretory phenotype, characterized by the release of pro-inflammatory cytokines, chemokines, and 19 tissue-damaging enzymes [2]. In parallel, aging disrupts the composition and function of extracellular 20 vesicles (EVs), key mediators of intercellular communication that increasingly reflect and propagate 21 systemic inflammatory signals [3]. Collectively, these mechanisms contribute to inflamm-aging, a 22 chronic, sterile, low-grade inflammatory state [1; 2;
Keywords: extracellular vesicles, Aging, Immunity, Mitochondria, cytokines. 15
Received: 25 Jul 2025; Accepted: 29 Jul 2025.
Copyright: © 2025 Caruso and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Calogero Caruso, University of Palermo, Palermo, Italy
Xin Zhang, Duke University Hospital, Durham, United States
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