REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1675480
Lactylation as a Cross-regulatory Node in Tumor Metabolism and Epigenetics: Insights and Therapeutic Implications
Provisionally accepted
- Xinxiang Medical University, Xinxiang, China
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Lactylation serves as a pivotal cross-regulatory mechanism linking tumor metabolic reprogramming and epigenetic regulation. This review comprehensively summarizes the mechanisms of lactylation writers, erasers, and readers, highlighting their tumor-specific functions, roles in immunosuppressive tumor microenvironment (TME) remodeling, and contributions to therapeutic resistance. Emerging targeting strategies, including metabolic inhibitors, epigenetic modulators, and combination immunotherapies, exhibit promising preclinical efficacy,highlighting their potential for clinical translation in overcoming therapy resistance and improving cancer immunotherapy.
Keywords: lactylation, metabolic reprogramming, Epigenetic regulation, Warburg effect, therapeutic
Received: 29 Jul 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Zhuangwei, Yang, Liu, Shi, Wang, Wu and Jiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Junna Jiao, Xinxiang Medical University, Xinxiang, China
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