REVIEW article
Front. Immunol.
Sec. Inflammation
Therapeutic Potential of Exosomes in Periodontal Regeneration: Immunomodulatory and Tissue-Repair Mechanisms
Provisionally accepted
- China-Japan Union Hospital of Jilin University, Changchun, China
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Periodontitis, a chronic inflammatory disease leading to irreversible tissue destruction, is a highly prevalent oral disease. The clinical management of periodontitis is challenging because conventional treatments like mechanical debridement and antibiotic therapy lack sufficient regenerative efficacy to achieve functional periodontal restoration. In recent years, exosomes have received widespread attention as cell-free therapeutic agents for periodontal tissue regeneration. This article reviews the dual role of exosomes in modulating immune response and promoting tissue repair, and briefly describes the exosome delivery systems studied so far. The aim of this review is to emphasize the important position occupied by cell-derived exosomes in the treatment of periodontitis as well as the main mechanisms, and to explore novel targets for the treatment of periodontitis.
Keywords: periodontitis1, exosomes2, Immunomodulation3, immune cells4, periodontal tissue regeneration5, Alveolar bone regeneration6
Received: 29 Jul 2025; Accepted: 14 Nov 2025.
Copyright: © 2025 Yang, Han, Wang, Ai, Wang and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenzhi Song, songwz@jlu.edu.cn
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