CASE REPORT article
Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1676906
Fecal Microbiota Transplantation as Salvage Therapy for Disseminated Strongyloidiasis in an Immunosuppressed Patient: A Case Report
Provisionally accepted
- 1The 925th hospital of PLA, Guiyang, China
- 2The 925th Hospital of the People's Liberation Army Joint Logistics Support Force, Guiyang, China
- 3People's Liberation Army General Hospital of Southern Theatre Command, Guangzhou, China
- 4923th Hospital of PLA Joint Logistics Support Force, nanning, China
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Background: Disseminated strongyloidiasis carries high mortality in immunosuppressed populations. We report a case of refractory Strongyloides stercoralis-induced severe diarrhea and sepsis successfully treated with fecal microbiota transplantation (FMT). Case Presentation: A 68-year-old male with nephrotic syndrome on long-term glucocorticoids developed hyperinfection syndrome manifesting as septic shock, multiorgan dysfunction, and intractable diarrhea (>30 episodes/day). Conventional therapies including antiparasitics (albendazole), antibiotics, and probiotics failed. FMT achieved rapid symptom resolution and microbiota restoration. Conclusion: This case highlights FMT's potential in modulating gut-parasite interactions and suggests its role as adjunctive therapy for parasitic hyperinfection syndromes.
Keywords: Strongyloides stercoralis, fecal microbiota transplantation, Sepsis, Immunosuppression, Multiorgan dysfunction
Received: 31 Jul 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Fu, Peng and Geng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Geng, drggyn@163.com
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