SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1677872
This article is part of the Research TopicImmunosenescence and Inflammaging: Modulating Immune Function through Diet, Lifestyle, and Therapeutic InterventionsView all 4 articles
Mind-body therapies for pro-inflammatory cytokines in patients with depression: Findings from a systematic review of randomized controlled trials
Provisionally accepted- 1Southwest University, Chongqing, China
- 2Shanghai University of Sport, Shanghai, China
- 3Yunnan Normal University, Kunming, China
- 4Tianjin University, Tianjin, China
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Objective: Depression is one of the most common mental disorders and is the leading cause of disability worldwide. The objective of this systematic review was to synthesize the latest evidence from randomized controlled trials (RCTs) regarding the effectiveness of mind-body therapies (MBTs) on pro-inflammatory cytokines in patients with depression. Methods: A literature search was conducted in five electronic databases—PubMed, Embase, Web of Science, EBSCOhost, and Scopus. The quality of the included studies was evaluated using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). A narrative synthesis of the included studies was conducted. Results: The 12 RCTs provided 21 pieces of evidence involving a total of 1,058 patients with depression. The risk of bias among the included studies ranged from low to high, with 4 studies assessed as low risk, 4 as some concerns, and 4 as high risk. Among the 21 pieces of evidence evaluated, 14 supported the positive impact of MBTs on pro-inflammatory cytokine levels in patients with depression. Conclusion: MBTs have been widely recognized in nursing for their low risk and substantial benefits, and they hold promise as a complementary therapy to improve physiological health outcomes in patients with depression. However, the studies included commonly exhibit potential limitations in terms of intervention materials, adherence, and outcome measures. It is suggested that future research should further examine the existing evidence to strengthen the empirical foundation for incorporating MBTs into nursing care for depression.
Keywords: Mind-Body Therapies, Inflammatory markers, Inflammation, Depression, Systematic review
Received: 01 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Mei, Luo, Cai, Chifong, Wang, Jia, Chen and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ranran He, 1344703636@qq.com
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