CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1679036
This article is part of the Research TopicCase Reports in Autoimmune and Autoinflammatory Disorders: Volume IIView all 32 articles
Lupus Mesenteric Vasculitis Disguised as Urticaria with Abdominal Pain: a case report with 10 months follow-up observation
Provisionally accepted
- 1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- 2College of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease 19 characterized by multi-system involvement, with gastrointestinal 20 manifestations often presenting diagnostic challenges due to their 21 non-specificity. Mesenteric vasculitis, a rare but severe complication of SLE, 22 carries a high misdiagnosis rate and mortality if it cannot be identified promptly. 23 We report a case of a 27-year-old female with SLE presenting initially with 24 atypical abdominal pain and duodenal edema. Due to her history of urticaria, 25 she was initially mistaken for urticaria related abdominal pain. After a correct 26 diagnosis, there was still progress despite conventional glucocorticoid therapy. 27 The patient achieved remission following high-dose methylprednisolone pulse 28 therapy, with sustained stability over 10 months of follow-up. This highlights a 29 focus on long-term efficacy with extended follow-up, which is less common in 30 similar past reports. This case highlights the importance of early recognition of 31 SLE-related mesenteric vasculitis, particularly in patients with non-specific 32 gastrointestinal symptoms, and emphasizes the necessity of aggressive 33
Keywords: systemic lupus erythematosus, Mesenteric vasculitis, glucocorticoid, Nonspecific abdominal pain, case report
Received: 04 Aug 2025; Accepted: 17 Oct 2025.
Copyright: © 2025 Huang, Mo and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenhao Ye, zjganbw@126.com
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