REVIEW article
Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1682934
This article is part of the Research TopicCommunity Series in Research Advances of Tuberculosis Vaccine and its Implication on COVID-19: Volume IIIView all 8 articles
Different antibody isotypes against tuberculosis: what we know and what we need to know
Provisionally accepted
- China Agricultural University, Beijing, China
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Humoral Immunity plays an important role during Mycobacterium tuberculosis(Mtb) infection. In mouse models, polyvalent and monoclonal antibodies targeting Mtb provided some protection against tuberculosis (TB). The five human antibody isotypes (IgG, IgM, IgA, IgE, and IgD) mediate an array of functional activities against bacterial infections, including neutralization, antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, and complement activation. Different antibody isotypes have functions by through different protective mechanisms based on the biological structures and pathways involved. In this review, we summarize the research progress on the different isotypes of antibodies against TB, and discuss the antibody-based strategies against tuberculosis, the potentiality of antibodies in TB diagnosis, and suggest further research directions, including investigating the mechanisms of different isotypes of antibody-mediated protection against TB, identifying correlates of immunity, and novel vaccines development. discuss the antibody strategies for TB treatment and vaccine development, and suggest directions for future research on antibody isotypes against TB.
Keywords: mycobacterial tuberculosis, Tuberculosis, humoral immunity, Antibody isotype, BCG
Received: 10 Aug 2025; Accepted: 07 Oct 2025.
Copyright: © 2025 Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Li, boyleehao@hotmail.com
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