EDITORIAL article
Front. Immunol.
Sec. Mucosal Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1682978
This article is part of the Research TopicNatural Products and Intestinal Mucosal ImmunityView all 11 articles
Editorial: Natural Products and Intestinal Mucosal Immunity
Provisionally accepted
- 1Beijing University of Chinese Medicine, Beijing, China
- 2Chinese Academy of Sciences, Beijing, China
- 3The University of Texas Health Science Center at San Antonio, San Antonio, United States
- 4First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China
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intestinal immunity at molecular, cellular, and multi-omic levels. The ten included articles here explore diverse mechanisms from mitochondrial homeostasis, cell death mechanisms, microbiome crosstalk, to clinical translation, collectively advancing natural products from empiric remedies to rationally based therapeutics.As the forefront of intestinal defense, disruption of the epithelial barrier initiates Future research priorities for this field encompass several key areas. First, developing precision-targeted nanoparticle formulations to achieve maximum bioavailability and tissue-selective targeting. Second, engineering protective microbiomes by synergistic combinations of phytochemical prebiotics, probiotics, and other applicable approaches. Third, identifying additional natural products with the ability to modulate intestinal mucosal immunity and establishing a multidimensional methodological approach to elucidate the mechanisms of action, thereby laying a foundation for further clinical applications. Fourth, conducting rigorous clinical benchmarking via randomized controlled trials of natural products compared with biologics in UC, irColitis, and related conditions, to further validate the clinical effectiveness of natural products.
Keywords: Natural Products, intestinal mucosal immunity, Intestinal Diseases, gut microbiome, intestinal inflammation, Gut barrier
Received: 10 Aug 2025; Accepted: 18 Sep 2025.
Copyright: © 2025 Yao, Mo, Sui, Wan and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haiqiang Yao, haiqiangyao@outlook.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.