MINI REVIEW article
Front. Immunol.
Sec. B Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1684210
This article is part of the Research TopicDecoding the Spectrum of Plasma Cell Heterogeneity: Insights into Maturity and LongevityView all articles
Developmental Trajectory of long-lived plasma cells
Provisionally accepted
Takuya Koike1
Wataru Ise2*- 1University of Tokyo, Tokyo, Japan
- 2Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan
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Long-lived plasma cells (LLPCs), which continuously secrete antibodies, play a central role in humoral immunity and form the foundation of effective vaccine strategies. The anatomical segregation between the tissues where plasma cells are generated and where they are maintained suggests that both cell-intrinsic and extrinsic factors contribute to their longevity; however, the underlying cellular and molecular mechanisms remain largely unclear. In this review, we summarize recent advances in elucidating the regulation of plasma cell survival at both induction and effector sites. We particularly highlight potential LLPC precursors among newly generated plasma cells in secondary lymphoid tissues, and their subsequent maturation and differentiation into bone fide LLPCs within the bone marrow.
Keywords: LLPC, Bone Marrow, antibody, niche, Vaccine
Received: 12 Aug 2025; Accepted: 09 Sep 2025.
Copyright: © 2025 Koike and Ise. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wataru Ise, Center for Infectious Disease Education and Research, Osaka University, Osaka, 565-0873, Japan
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