REVIEW article
Front. Immunol.
Sec. Inflammation
Research Advances of Pan-Immune Inflammation Value (PIV) in Rheumatoid Arthritis
Provisionally accepted
- 1Shenyang Heping District Beishi community Health Service Center, Shenyang, China
- 2Central Hospital Affiliated to Shenyang Medical College, Shenyang, China
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Abstract: Rheumatoid arthritis (RA) is a persistent autoimmune condition marked by systemic inflammation, primarily impacting multiple joints and causing irreversible structural and functional damage. While the pathophysiology remains complex, immune cells and cytokines are crucial to the disease's initiation and progression. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are routinely used to assess disease activity. However, in recent years, the pan-immune inflammatory value (PIV) has emerged as a focal point of inquiry. As a new, single biomarker calculated from various routine blood parameters, PIV accurately reflects the patient's comprehensive systemic immune-inflammatory condition and offers a more integrated perspective than traditional markers. This article provides a focused analysis of the potential role and clinical significance of PIV in assessing the activity and advancement of RA.
Keywords: Rheumatoid arthritis pannus, immune cells, Cytokines, Peripheral Blood, pan-immune inflammation value
Received: 27 Aug 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Zhou, Cheng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinyu Cheng, cxy6816@126.com
Junjie Zhang, zhangjunjie34@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.